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Binding affinity ranges of Aβ42 or α-BTX to orthosteric binding sites. All affinity ranges were calculated by SeeSAR.
| Binding Site Interface | Aβ42 Affinity (Ki calc) | a-BTX Affinity (Ki calc) |
|---|---|---|
| α7-α7 | Low nM | High pM |
| α7-Dupα7 | mM | >mM |
| Dupα7-α7 | High nM to Low μM | >mM |
| Dupα7-Dupα7 | mM | >mM |
