Table 2.

Mean knee temperature (°C) during the visit (IRT0–IRT5) after administration of 2 g of Exten(d) for 30 days to volunteers compared to placebo. Values reported are means ± standard error of the mean.

Variables	Exten(d) (n = 13)		p	Control (n = 15)		p	p	p
	Day 0	Day 30	Intra	Day 0	Day 30	Intra	Inter T0	Inter T1
IRT0	31.05 ± 0.30	29.33 ± 0.46	0.008	30.08 ± 0.21	28.63 ± 0.32	0.001	0.013	0.387
IRT1	30.44 ± 0.27	29.18 ± 0.48	0.042	29.86 ± 0.20	28.82 ± 0.30	0.014	0.034	0.345
IRT2	28.62 ± 0.29	27.69 ± 0.40	0.043	27.98 ± 0.27	27.74 ± 0.31	0.434	0.116	0.915
IRT3	31.18 ± 0.26	30.68 ± 0.41	0.247	30.08 ± 0.18	29.80 ± 0.31	0.435	0.002	0.098
IRT4	30.15 ± 0.32	29.19 ± 0.45	0.144	29.59 ± 0.30	29.00 ± 0.30	0.101	0.231	0.394
IRT5	27.55 ± 0.33	26.88± 0.52	0.555	27.08 ± 0.31	26.61 ± 0.37	0.468	0.240	0.394

IRT0 = basal round; IRT1 = after acclimation to room temperature; IRT2 = after first biomechanical running test; IRT3 = shortly before incremental test to exhaustion; IRT4 = immediately post-incremental exercise test to exhaustion; IRT5 = after cooling down. Significant differences (p < 0.05) are highlighted in bold.