Table 2.
miRNA profiles in periodontal disease and systemic disease.
| mRNAs | Correlation with Systemic Disease | Activity | Expression | References |
|---|---|---|---|---|
| mRNA-146a | Heart disease | Chronic inflammatory disorders, both cardiac and periodontal diseases. Acts against Th1 and Th2 cells, shifting the balance towards Th1. | Upregulation in tissues of patient with periodontal and heart diseases | [30] |
| mRNA-let7 | Heart disease | Inhibition of angiogenesis through up-regulation of TSP-1. | Upregulation in tissues of patient with periodontal and heart diseases. | [43,45] |
| mRNA-146 | Diabetes | Negative feedback control of NFκB target genes and are involved in oxidative stress by targeting SOD. | Overexpression in crevicular fluid of diabetic patients with periodontitis. | [60] |
| mRNA-155 | Diabetes | Negative feedback control of NFκB target genes and are involved in oxidative stress by targeting SOD. | Overexpression in crevicular fluid of diabetic patients with periodontitis. | [60] |
| mRNA-223 | Diabetes | Increased expression of TNF-α. | Upregulation in tissue, crevicular fluid and serum in patients with diabetes and periodontitis. | [71] |
| mRNA-203 | Diabetes | Reduced expression of TNF-α. | Downregulation in tissue, crevicular fluid and serum in patients with diabetes and periodontitis | [71] |
| mRNA-200-3p | Diabetes | Increased expression of TNF-α. | Upregulation in tissue, crevicular fluid and serum in patients with diabetes and periodontitis. | [71] |
| mRNA-200b-5p | Obesity | Reduced expression of its target genes ZEB1, ZEB2, GATA2 and KDR involved in re-epithelisation. | Upregulation in tissue of obese patients with periodontitis. | [73] |
| mRNA-200b/c | Obesity | Alters TLR4 signalling in macrophages. | Upregulation in tissue of obese patients with periodontitis. | [40] |