Table 2.

Biodistribution of ¹¹¹In-DOTA-EB-cRGDfK after tail-vein injection in the U-87 MG tumor bearing mice.

Organ	2 h	24 h	48 h	72 h	96 h
Blood	13.46 ± 0.92	1.90 ± 0.16	1.44 ± 0.19	1.12 ± 0.38	0.88 ± 0.05
Skin	6.03 ± 0.7	5.80 ± 0.79	5.52 ± 0.84	5.56 ± 0.70	5.01 ± 1.03
Muscle	2.18 ± 0.27	1.19 ± 0.11	1.19 ± 0.14	1.26 ± 0.23	1.02 ± 0.14
Bone	1.95 ± 0.37	1.69 ± 0.56	1.38 ± 0.48	1.33 ± 0.70	0.96 ± 0.16
Brain	0.46 ± 0.09	0.32 ± 0.03	0.32 ± 0.08	0.30 ± 0.12	0.27 ± 0.03
Bladder	9.1 ± 1.55	7.86 ± 1.16	7.05 ± 1.50	6.53 ± 0.86	6.43 ± 2.03
Pancreas	2.42 ± 0.14	1.46 ± 0.13	1.38 ± 0.27	1.48 ± 0.20	1.25 ± 0.18
Spleen	9.73 ± 2.1	12.10 ± 1.84	12.88 ± 2.78	11.06 ± 2.85	8.83 ± 3.11
Stomach	5.72 ± 0.93	4.57 ± 0.63	4.14 ± 0.66	3.53 ± 0.70	2.17 ± 0.12
Small intestine	10.03 ± 1.05	7.01 ± 2.88	6.13 ± 2.4	6.91 ± 1.31	4.20 ± 2.13
Large intestine	4.91 ± 0.39	3.38 ± 0.58	2.75 ± 0.54	3.14 ± 1.01	1.67 ± 0.25
Bile	5.65 ± 6.39	2.32 ± 1.25	0.67 ± 0.51	3.49 ± 3.05	0.23 ± 0.13
Liver	7.79 ± 1.26	5.79 ± 0.37	6.15 ± 0.95	7.15 ± 2.51	5.70 ± 0.29
Kidney	13.34 ± 1.08	14.42 ± 0.38	13.41 ± 2.06	13.70 ± 2.73	11.01 ± 0.50
Heart	4.65 ± 0.27	2.79 ± 0.06	2.75 ± 0.55	2.62 ± 0.59	2.09 ± 0.21
Lung	7.11 ± 0.69	3.11 ± 0.28	3.92 ± 2.29	2.91 ± 0.31	2.92 ± 0.92
Tumor	19.44 ± 2.20	27.12 ± 2.70	26.53 ± 3.92	26.44 ± 6.16	18.55 ± 2.01
T/M ratio	8.92	22.79	22.29	20.98	18.19
T/B ratio	1.44	14.27	18.42	23.61	21.08

Values were presented as %ID/g, mean ± SD, (n = 4–5 at each time point). T/M, tumor/muscle; T/B, tumor/blood.