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. 2021 May 22;22(11):5465. doi: 10.3390/ijms22115465

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolomic analysis of leukemic cells treated with urolithin A and B for 48 h: (A) PCA analysis of total metabolites of Jurkat and K562; (B) expression heat map of differential metabolites expressed in control and urolithin A- and urolithin B-treated cells; (C) top pathways enriched in Jurkat and K562 control and urolithin A- and urolithin B-treated cells; (D) pathway network analysis of Jurkat and K562 control and urolithin A- and urolithin B-treated cells; (E) VIP score for differentially expressed metabolites during urolithin A and B treatment.