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. 2021 May 22;26(11):3100. doi: 10.3390/molecules26113100

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 17 — Synthesis of triazole-linked dinucleotides. Reaction conditions: (a) CuBr·SMe₂, t-BuOH, DMF, rt; (b) EtN(i-Pr)₂, ClP(OCH₂CH₂CN)N(i-Pr)₂, CH₂Cl₂, r.t. The triazole linkage is represented as t.