Scheme 27.
Synthesis of boron-cluster-modified anti-EGFR antisense oligonucleotides. Click reaction conditions: azide (50 eq.), CuSO4/TBTA (1:1) (25 eq.), NaAsc (40 eq.), DMSO/tBuOH/H2O (3:1:1), 4 h, r.t. (61% yield).
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