Table 2.
Escherichia coli | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 2,481 isolates) | (N = 2,458 isolates) | (N = 2,509 isolates) | (N = 3,085 isolates) | (N = 4,149 isolates) | (N = 14,682 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 1100 | 761 | 69.2 | 1130 | 793 | 70.2 | 1158 | 803 | 69.3 | 1100 | 987 | 89.7 | 1800 | 1654 | 91.9 | 6288 | 4998 | 79.5 | 0.460 |
AMX/CLA | 1920 | 1679 | 87.4 | 2100 | 1805 | 86 | 2103 | 1874 | 89.1 | 2700 | 2326 | 86.1 | 3258 | 2825 | 86.7 | 12,081 | 10,509 | 87 | 0.835 |
CZN | 333 | 126 | 37.8 | 999 | 841 | 84.2 | 666 | 470 | 70.6 | 987 | 631 | 63.9 | 1852 | 1412 | 76.2 | 4837 | 3480 | 71.9 | 0.683 |
CRX | 788 | 660 | 83.8 | 1125 | 828 | 73.6 | 547 | 378 | 69.1 | 981 | 732 | 74.6 | 1987 | 1505 | 75.7 | 5428 | 4103 | 75.6 | 0.911 |
CFX | 1968 | 819 | 41.6 | 645 | 496 | 76.9 | 752 | 432 | 57.4 | 896 | 772 | 86.2 | 879 | 534 | 60.8 | 5140 | 3053 | 59.4 | 0.981 |
CTM | 456 | 253 | 55.5 | 488 | 282 | 57.8 | 456 | 238 | 52.2 | 541 | 290 | 53.6 | 654 | 274 | 41.9 | 2595 | 1337 | 51.5 | 0.920 |
CTX | 2388 | 1764 | 73.9 | 1933 | 1757 | 90.9 | 1901 | 1610 | 84.7 | 2456 | 2134 | 86.9 | 3896 | 3007 | 77.2 | 12,574 | 10,272 | 81.7 | 0.682 |
CZM | 1963 | 1059 | 53.9 | 1025 | 896 | 87.4 | 2005 | 1113 | 55.5 | 1754 | 1275 | 72.7 | 1785 | 1384 | 77.5 | 8532 | 5727 | 67.1 | 0.998 |
CPM | 1347 | 1007 | 74.8 | 1987 | 1775 | 89.3 | 2111 | 1764 | 83.6 | 2666 | 2158 | 80.9 | 3101 | 2849 | 91.9 | 11,212 | 9553 | 85.2 | 0.846 |
IPM | 2477 | 2451 | 99 | 2358 | 2158 | 91.5 | 2430 | 2395 | 98.6 | 3081 | 3069 | 99.6 | 4130 | 4022 | 97.4 | 14,476 | 14,095 | 97.4 | 0.676 |
MPM | 2480 | 2412 | 97.3 | 2400 | 2238 | 93.3 | 2414 | 2392 | 99.1 | 3074 | 3048 | 99.2 | 4099 | 4022 | 98.1 | 14,467 | 14,112 | 97.5 | 0.654 |
PIP-TZP | 2360 | 2270 | 96.2 | 2347 | 2146 | 91.4 | 2456 | 2322 | 94.5 | 2996 | 2882 | 96.2 | 3896 | 3533 | 90.7 | 14,055 | 13,153 | 93.6 | 0.805 |
TMP-SMZ | 1456 | 1293 | 88.8 | 1745 | 1463 | 83.8 | 1736 | 1249 | 71.9 | 1987 | 1775 | 89.3 | 2898 | 2589 | 89.3 | 9822 | 8369 | 85.2 | 0.529 |
GMN | 2223 | 2128 | 95.7 | 2314 | 2178 | 94.1 | 2300 | 2124 | 92.3 | 2965 | 2742 | 92.5 | 3991 | 3589 | 89.9 | 13,793 | 12,761 | 92.5 | 0.726 |
ACN | 2470 | 2135 | 86.4 | 2389 | 2400 | 100.5 | 2490 | 2414 | 96.9 | 3030 | 3009 | 99.3 | 4110 | 4030 | 98.1 | 14,489 | 13,988 | 96.5 | 0.697 |
CIP | 2001 | 1726 | 86.3 | 1999 | 1804 | 90.2 | 1800 | 1737 | 96.5 | 2789 | 2240 | 80.3 | 3008 | 2951 | 98.1 | 11,597 | 10,458 | 90.2 | 0.739 |
OXN | 1136 | 785 | 69.1 | 1107 | 909 | 82.1 | 700 | 612 | 87.4 | 698 | 548 | 78.5 | 687 | 442 | 64.3 | 4328 | 3296 | 76.2 | 0.967 |
LVX | 1147 | 785 | 68.4 | 1165 | 918 | 78.8 | 565 | 438 | 77.5 | 1365 | 1016 | 74.4 | 1777 | 1393 | 78.4 | 6019 | 4550 | 75.6 | 0.923 |
NFT | 1455 | 1241 | 85.3 | 2411 | 2317 | 96.1 | 2425 | 2314 | 95.4 | 2905 | 2704 | 93.1 | 3896 | 3790 | 97.3 | 13,092 | 12,366 | 94.5 | 0.489 |
TGN | 2377 | 2269 | 95.5 | 2450 | 2420 | 98.8 | 2500 | 2499 | 100 | 3083 | 3069 | 99.5 | 4144 | 4131 | 99.7 | 14,554 | 14,388 | 98.9 | 0.420 |
CLN | 1365 | 1106 | 81 | 1130 | 722 | 63.9 | 789 | 570 | 72.2 | 2029 | 1016 | 50.1 | 4011 | 3974 | 99.1 | 9324 | 7388 | 79.2 | 0.120 |
Klebsiella species | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 1,000 isolates) | (N = 839 isolates) | (N = 1,299 isolates) | (N = 1,357 isolates) | (N = 1,356 isolates) | (N = 5,851 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 300 | 206 | 68.7 | 222 | 172 | 77.5 | 221 | 94 | 42.5 | 801 | 611 | 76.3 | 512 | 333 | 65 | 2056 | 1416 | 68.9 | 0.258 |
AMX/CLA | 654 | 534 | 81.7 | 654 | 565 | 86.4 | 906 | 841 | 92.8 | 1001 | 938 | 93.7 | 896 | 739 | 82.5 | 4111 | 3617 | 88 | 0.772 |
CZN | 159 | 75 | 47.2 | 400 | 312 | 78 | 456 | 356 | 78.1 | 562 | 467 | 83.1 | 753 | 462 | 61.4 | 2330 | 1672 | 71.8 | 0.786 |
CRX | 654 | 223 | 34.1 | 258 | 137 | 53.1 | 358 | 278 | 77.7 | 452 | 354 | 78.3 | 963 | 369 | 38.3 | 2685 | 1361 | 50.7 | 0.975 |
CFX | 700 | 444 | 63.4 | 402 | 321 | 79.9 | 456 | 295 | 64.7 | 458 | 370 | 80.8 | 456 | 269 | 59 | 2472 | 1699 | 68.7 | 0.989 |
CTM | 112 | 82 | 73.2 | 111 | 86 | 77.5 | 255 | 104 | 40.8 | 320 | 134 | 41.9 | 358 | 114 | 31.8 | 1156 | 520 | 45 | 0.997 |
CTX | 753 | 543 | 72.1 | 654 | 507 | 77.5 | 801 | 770 | 96.1 | 987 | 887 | 89.9 | 1,196 | 851 | 71.2 | 4391 | 3558 | 81 | 0.607 |
CZM | 656 | 367 | 55.9 | 456 | 326 | 71.5 | 687 | 413 | 60.1 | 454 | 394 | 86.8 | 756 | 396 | 52.4 | 3009 | 1896 | 63 | 0.269 |
CPM | 550 | 310 | 56.4 | 654 | 589 | 90.1 | 1010 | 845 | 83.7 | 900 | 829 | 92.1 | 1120 | 814 | 72.7 | 4234 | 3387 | 80 | 0.821 |
IPM | 961 | 778 | 81 | 832 | 781 | 93.9 | 1190 | 1113 | 93.5 | 1290 | 1208 | 93.6 | 1310 | 1116 | 85.2 | 5583 | 4996 | 89.5 | 0.626 |
MPM | 800 | 742 | 92.8 | 765 | 731 | 95.6 | 1120 | 1104 | 98.6 | 1291 | 1207 | 93.5 | 1312 | 1104 | 84.1 | 5288 | 4888 | 92.4 | 0.544 |
PIP-TZP | 751 | 631 | 84 | 741 | 664 | 89.6 | 1130 | 933 | 82.6 | 1140 | 1021 | 89.6 | 1100 | 906 | 82.4 | 4862 | 4155 | 85.5 | 0.765 |
TMP-SMZ | 654 | 535 | 81.8 | 659 | 596 | 90.4 | 874 | 788 | 90.2 | 1122 | 903 | 80.5 | 1145 | 905 | 79 | 4454 | 3727 | 83.7 | 0.561 |
GMN | 963 | 696 | 72.3 | 801 | 700 | 87.4 | 1122 | 1019 | 90.8 | 1260 | 1167 | 92.6 | 1258 | 1152 | 91.6 | 5404 | 4734 | 87.6 | 0.462 |
ACN | 852 | 774 | 90.8 | 811 | 782 | 96.4 | 1125 | 1087 | 96.6 | 1290 | 1150 | 89.1 | 1322 | 1272 | 96.2 | 5400 | 5065 | 93.8 | 0.604 |
CIP | 789 | 652 | 82.6 | 753 | 686 | 91.1 | 1100 | 954 | 86.7 | 1299 | 1068 | 82.2 | 1300 | 916 | 70.5 | 5241 | 4276 | 81.6 | 0.641 |
OXN | 350 | 265 | 75.7 | 402 | 273 | 67.9 | 582 | 404 | 69.4 | 654 | 589 | 90.1 | 1101 | 789 | 71.7 | 3089 | 2320 | 75.1 | 0.624 |
LVX | 300 | 265 | 88.3 | 582 | 321 | 55.2 | 452 | 360 | 79.6 | 542 | 441 | 81.4 | 900 | 745 | 82.8 | 2776 | 2132 | 76.8 | 0.870 |
NFT | 258 | 137 | 53.1 | 456 | 322 | 70.6 | 652 | 505 | 77.5 | 521 | 478 | 91.7 | 456 | 379 | 83.1 | 2343 | 1821 | 77.7 | 0.106 |
TGN | 753 | 512 | 68 | 500 | 356 | 71.2 | 587 | 417 | 71 | 530 | 517 | 97.5 | 874 | 639 | 73.1 | 3244 | 2441 | 75.2 | 0.984 |
CLN | 466 | 378 | 81.1 | 665 | 654 | 98.3 | 1200 | 1179 | 98.3 | 529 | 517 | 97.7 | 1199 | 1023 | 85.3 | 4059 | 3751 | 92.4 | 0.736 |
Pseudomonas species | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 850 isolates) | (N = 806 isolates) | (N = 696 isolates) | (N = 733 isolates) | (N = 837 isolates) | (N = 3,922 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 221 | 46 | 20.8 | 400 | 193 | 48.3 | 333 | 269 | 80.8 | 401 | 377 | 94 | 514 | 441 | 85.8 | 1869 | 1326 | 70.9 | 0.636 |
AMX/CLA | 410 | 296 | 72.2 | 147 | 78 | 53.1 | 415 | 300 | 72.3 | 159 | 94 | 59.1 | 652 | 416 | 63.8 | 1783 | 1184 | 66.4 | 0.519 |
CZN | 119 | 61 | 51.3 | 302 | 111 | 36.8 | 512 | 264 | 51.6 | 412 | 303 | 73.5 | 452 | 329 | 72.8 | 1797 | 1068 | 59.4 | 0.046 |
CRX | 300 | 109 | 36.3 | 411 | 178 | 43.3 | 466 | 222 | 47.6 | 454 | 301 | 66.3 | 552 | 489 | 88.6 | 2183 | 1299 | 59.5 | 0.188 |
CFX | 147 | 76 | 51.7 | 430 | 188 | 43.7 | 501 | 249 | 49.7 | 541 | 334 | 61.7 | 611 | 401 | 65.6 | 2230 | 1248 | 56 | 0.186 |
CTM | 109 | 29 | 26.6 | 156 | 67 | 42.9 | 247 | 110 | 44.5 | 268 | 137 | 51.1 | 254 | 133 | 52.4 | 1034 | 476 | 46 | 0.923 |
CTX | 358 | 276 | 77.1 | 547 | 369 | 67.5 | 240 | 110 | 45.8 | 260 | 137 | 52.7 | 219 | 133 | 60.7 | 1624 | 1025 | 63.1 | 0.746 |
CZM | 800 | 676 | 84.5 | 789 | 686 | 86.9 | 614 | 495 | 80.6 | 660 | 480 | 72.7 | 653 | 558 | 85.5 | 3516 | 2895 | 82.3 | 0.952 |
CPM | 598 | 300 | 50.2 | 658 | 567 | 86.2 | 611 | 512 | 83.8 | 614 | 500 | 81.4 | 678 | 568 | 83.8 | 3159 | 2447 | 77.5 | 0.961 |
IPM | 753 | 541 | 71.8 | 782 | 614 | 78.5 | 660 | 574 | 87 | 603 | 576 | 95.5 | 801 | 710 | 88.6 | 3599 | 3015 | 83.8 | 0.925 |
MPM | 741 | 564 | 76.1 | 788 | 617 | 78.3 | 671 | 570 | 84.9 | 654 | 582 | 89 | 822 | 713 | 86.7 | 3676 | 3046 | 82.9 | 0.944 |
PIP-TZP | 820 | 631 | 77 | 799 | 692 | 86.6 | 680 | 590 | 86.8 | 721 | 608 | 84.3 | 810 | 742 | 91.6 | 3830 | 3263 | 85.2 | 0.956 |
TMP-SMZ | 658 | 321 | 48.8 | 654 | 456 | 69.7 | 514 | 477 | 92.8 | 654 | 522 | 79.8 | 769 | 687 | 89.3 | 3249 | 2463 | 75.8 | 0.535 |
GMN | 830 | 744 | 89.6 | 800 | 730 | 91.3 | 688 | 642 | 93.3 | 701 | 672 | 95.9 | 780 | 759 | 97.3 | 3799 | 3547 | 93.4 | 0.989 |
ACN | 840 | 755 | 89.9 | 801 | 756 | 94.4 | 680 | 665 | 97.8 | 699 | 686 | 98.1 | 820 | 784 | 95.6 | 3840 | 3646 | 94.9 | 0.990 |
CIP | 801 | 631 | 78.8 | 771 | 646 | 83.8 | 670 | 604 | 90.1 | 652 | 597 | 91.6 | 700 | 667 | 95.3 | 3594 | 145 | 87.5 | 0.997 |
OXN | 80 | 13 | 16.3 | 154 | 71 | 46.1 | 230 | 110 | 47.8 | 325 | 187 | 57.5 | 400 | 191 | 47.8 | 1189 | 572 | 48.1 | 0.030 |
LVX | 775 | 608 | 78.5 | 658 | 492 | 74.8 | 677 | 369 | 54.5 | 541 | 359 | 66.4 | 521 | 381 | 73.1 | 3172 | 2209 | 69.6 | 0.921 |
NFT | 302 | 111 | 36.8 | 321 | 128 | 39.9 | 321 | 177 | 55.1 | 428 | 201 | 47 | 451 | 290 | 64.3 | 1823 | 907 | 49.8 | 0.491 |
TGN | 346 | 339 | 98 | 420 | 409 | 97.4 | 511 | 498 | 97.5 | 541 | 533 | 98.5 | 681 | 678 | 99.6 | 2499 | 2457 | 98.3 | 0.142 |
CLN | 711 | 706 | 99.3 | 670 | 661 | 98.7 | 587 | 571 | 97.3 | 301 | 291 | 96.7 | 328 | 321 | 97.9 | 2597 | 2550 | 98.2 | 0.853 |
Acinetobacter species | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 611 isolates) | (N = 275 isolates) | (N = 280 isolates) | (N = 262 isolates) | (N = 182 isolates) | (N = 1,610 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 90 | 33 | 36.7 | 150 | 74 | 49.3 | 320 | 110 | 34.4 | 264 | 130 | 49.2 | 275 | 142 | 51.6 | 1099 | 489 | 44.5 | 0.262 |
AMX/CLA | 110 | 29 | 26.4 | 120 | 53 | 44.2 | 168 | 76 | 45.2 | 191 | 91 | 47.6 | 201 | 103 | 51.2 | 790 | 352 | 44.6 | 0.291 |
CZN | 60 | 19 | 31.7 | 60 | 21 | 35 | 96 | 29 | 30.2 | 67 | 34 | 50.7 | 79 | 44 | 55.7 | 362 | 147 | 40.6 | 0.538 |
CRX | 75 | 24 | 32 | 82 | 36 | 43.9 | 78 | 33 | 42.3 | 86 | 41 | 47.7 | 98 | 53 | 54.1 | 419 | 187 | 44.6 | 0.480 |
CFX | 64 | 11 | 17.2 | 70 | 24 | 34.3 | 77 | 23 | 29.9 | 76 | 36 | 47.4 | 88 | 47 | 53.4 | 375 | 141 | 37.6 | 0.101 |
CTM | 58 | 10 | 17.2 | 35 | 10 | 28.6 | 34 | 12 | 35.3 | 39 | 17 | 43.6 | 47 | 26 | 55.3 | 213 | 75 | 35.2 | 0.551 |
CTX | 86 | 18 | 20.9 | 31 | 14 | 45.2 | 33 | 22 | 66.7 | 71 | 29 | 40.8 | 76 | 38 | 50 | 297 | 121 | 40.7 | 0.478 |
CZM | 64 | 14 | 21.9 | 43 | 21 | 48.8 | 79 | 33 | 41.8 | 98 | 46 | 46.9 | 98 | 51 | 52 | 382 | 165 | 43.2 | 0.523 |
CPM | 23 | 3 | 13 | 29 | 11 | 37.9 | 39 | 17 | 43.6 | 70 | 36 | 51.4 | 81 | 43 | 53.1 | 242 | 110 | 45.5 | 0.573 |
IPM | 240 | 62 | 25.8 | 78 | 35 | 44.9 | 108 | 50 | 46.3 | 130 | 70 | 53.8 | 157 | 79 | 50.3 | 713 | 296 | 41.5 | 0.450 |
MPM | 149 | 35 | 23.5 | 127 | 62 | 48.8 | 100 | 50 | 50 | 129 | 70 | 54.3 | 171 | 91 | 53.2 | 676 | 308 | 45.6 | 0.112 |
PIP-TZP | 97 | 17 | 17.5 | 89 | 44 | 49.4 | 70 | 38 | 54.3 | 90 | 47 | 52.2 | 110 | 59 | 53.6 | 456 | 205 | 45 | 0.550 |
TMP-SMZ | 310 | 75 | 24.2 | 348 | 172 | 49.4 | 287 | 141 | 49.1 | 220 | 115 | 52.3 | 300 | 177 | 59 | 1465 | 680 | 46.4 | 0.420 |
GMN | 378 | 93 | 24.6 | 186 | 144 | 77.4 | 190 | 88 | 46.3 | 171 | 91 | 53.2 | 240 | 127 | 52.9 | 1165 | 543 | 46.6 | 0.660 |
ACN | 220 | 49 | 22.3 | 189 | 84 | 44.4 | 121 | 56 | 46.3 | 155 | 80 | 51.6 | 168 | 94 | 56 | 853 | 363 | 42.6 | 0.413 |
CIP | 127 | 29 | 22.8 | 114 | 49 | 43 | 130 | 59 | 45.4 | 125 | 67 | 53.6 | 148 | 78 | 52.7 | 644 | 282 | 43.8 | 0.415 |
OXN | 89 | 21 | 23.6 | 94 | 36 | 38.3 | 111 | 48 | 43.2 | 122 | 67 | 54.9 | 139 | 73 | 52.5 | 555 | 245 | 44.1 | 0.322 |
LVX | 40 | 8 | 20 | 17 | 8 | 47.1 | 36 | 17 | 47.2 | 40 | 24 | 60 | 58 | 33 | 56.9 | 191 | 90 | 47.1 | 0.697 |
NFT | 128 | 41 | 32 | 321 | 77 | 24 | 310 | 140 | 45.2 | 290 | 151 | 52.1 | 287 | 151 | 52.6 | 1336 | 560 | 41.9 | 0.102 |
TGN | 369 | 350 | 94.9 | 197 | 188 | 95.4 | 142 | 139 | 97.9 | 148 | 138 | 93.2 | 113 | 108 | 95.6 | 969 | 923 | 95.3 | 0.022 |
CLN | 401 | 381 | 95 | 134 | 124 | 92.5 | 169 | 164 | 97 | 120 | 116 | 96.7 | 129 | 117 | 90.7 | 953 | 902 | 94.6 | 0.089 |
Proteus species | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 212 isolates) | (N = 192 isolates) | (N = 150 isolates) | (N = 135 isolates) | (N = 197 isolates) | (N = 886 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 200 | 92 | 46 | 186 | 89 | 47.8 | 74 | 40 | 54.1 | 99 | 59 | 59.6 | 181 | 100 | 55.2 | 740 | 380 | 51.4 | 0.527 |
AMX/CLA | 201 | 143 | 71.1 | 187 | 146 | 78.1 | 147 | 100 | 68 | 129 | 114 | 88.4 | 170 | 155 | 91.2 | 834 | 658 | 78.9 | 0.797 |
CZN | 107 | 48 | 44.9 | 180 | 99 | 55 | 140 | 126 | 90 | 125 | 101 | 80.8 | 190 | 132 | 69.5 | 742 | 506 | 68.2 | 0.828 |
CRX | 83 | 35 | 42.2 | 178 | 44 | 24.7 | 91 | 51 | 56 | 113 | 74 | 65.5 | 130 | 81 | 62.3 | 595 | 285 | 47.9 | 0.863 |
CFX | 60 | 19 | 31.7 | 62 | 27 | 43.5 | 89 | 49 | 55.1 | 128 | 77 | 60.2 | 191 | 110 | 57.6 | 530 | 282 | 53.2 | 0.266 |
CTM | 112 | 36 | 32.1 | 81 | 40 | 49.4 | 78 | 52 | 66.7 | 97 | 64 | 66 | 141 | 76 | 53.9 | 509 | 268 | 52.7 | 0.760 |
CTX | 203 | 112 | 55.2 | 179 | 133 | 74.3 | 130 | 121 | 93.1 | 127 | 100 | 78.7 | 180 | 161 | 89.4 | 819 | 627 | 76.6 | 0.878 |
CZM | 150 | 77 | 51.3 | 150 | 70 | 46.7 | 136 | 115 | 84.6 | 131 | 79 | 60.3 | 174 | 116 | 66.7 | 741 | 457 | 61.7 | 0.913 |
CPM | 90 | 41 | 45.6 | 128 | 63 | 49.2 | 137 | 71 | 51.8 | 131 | 118 | 90.1 | 179 | 127 | 70.9 | 665 | 420 | 63.2 | 0.692 |
IPM | 130 | 61 | 46.9 | 167 | 78 | 46.7 | 141 | 102 | 72.3 | 133 | 127 | 95.5 | 160 | 140 | 87.5 | 731 | 508 | 69.5 | 0.619 |
MPM | 200 | 121 | 60.5 | 189 | 150 | 79.4 | 149 | 130 | 87.2 | 121 | 101 | 83.5 | 189 | 179 | 94.7 | 848 | 681 | 80.3 | 0.821 |
PIP-TZP | 199 | 113 | 56.8 | 180 | 129 | 71.7 | 147 | 122 | 83 | 129 | 119 | 92.2 | 179 | 161 | 89.9 | 834 | 644 | 77.2 | 0.935 |
TMP-SMZ | 131 | 64 | 48.9 | 179 | 78 | 43.6 | 140 | 98 | 70 | 118 | 100 | 84.7 | 189 | 109 | 57.7 | 757 | 449 | 59.3 | 0.598 |
GMN | 141 | 88 | 62.4 | 167 | 109 | 65.3 | 145 | 140 | 96.6 | 120 | 102 | 85 | 170 | 148 | 87.1 | 743 | 587 | 79 | 0.417 |
ACN | 198 | 115 | 58.1 | 169 | 138 | 81.7 | 140 | 131 | 93.6 | 129 | 117 | 90.7 | 181 | 173 | 95.6 | 817 | 674 | 82.5 | 0.871 |
CIP | 191 | 93 | 48.7 | 187 | 108 | 57.8 | 135 | 133 | 98.5 | 131 | 122 | 93.1 | 179 | 147 | 82.1 | 823 | 603 | 73.3 | 0.775 |
OXN | 76 | 30 | 39.5 | 71 | 39 | 54.9 | 70 | 40 | 57.1 | 109 | 61 | 56 | 131 | 77 | 58.8 | 457 | 247 | 54 | 0.588 |
LVX | 40 | 17 | 42.5 | 40 | 22 | 55 | 66 | 37 | 56.1 | 97 | 55 | 56.7 | 137 | 81 | 59.1 | 380 | 212 | 55.8 | 0.218 |
NFT | 197 | 91 | 46.2 | 180 | 119 | 66.1 | 135 | 131 | 97 | 127 | 110 | 86.6 | 187 | 140 | 74.9 | 826 | 591 | 71.5 | 0.871 |
TGN | 190 | 176 | 92.6 | 188 | 178 | 94.7 | 139 | 134 | 96.4 | 130 | 123 | 94.6 | 191 | 188 | 98.4 | 838 | 799 | 95.3 | 0.759 |
CLN | 179 | 166 | 92.7 | 183 | 178 | 97.3 | 140 | 133 | 95 | 129 | 124 | 96.1 | 177 | 173 | 97.7 | 808 | 774 | 95.8 | 0.687 |
Enterobacter and Citrobacter species | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 162 isolates) | (N = 135 isolates) | (N = 85 isolates) | (N = 124 isolates) | (N = 297 isolates) | (N = 803 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 66 | 32 | 48.5 | 90 | 40 | 44.4 | 60 | 54 | 90 | 90 | 70 | 77.8 | 184 | 165 | 89.7 | 490 | 361 | 73.7 | 0.023 |
AMX/CLA | 39 | 17 | 43.6 | 36 | 11 | 30.6 | 60 | 29 | 48.3 | 66 | 40 | 60.6 | 83 | 60 | 72.3 | 284 | 157 | 55.3 | 0.084 |
CZN | 41 | 21 | 51.2 | 58 | 27 | 46.6 | 51 | 31 | 60.8 | 118 | 60 | 50.8 | 159 | 141 | 88.7 | 427 | 280 | 65.6 | 0.068 |
CRX | 58 | 27 | 46.6 | 78 | 33 | 42.3 | 78 | 41 | 52.6 | 120 | 66 | 55 | 87 | 71 | 81.6 | 421 | 238 | 56.5 | 0.003 |
CFX | 60 | 21 | 35 | 70 | 36 | 51.4 | 77 | 47 | 61 | 85 | 46 | 54.1 | 79 | 53 | 67.1 | 371 | 203 | 54.7 | 0.801 |
CTM | 81 | 33 | 40.7 | 89 | 44 | 49.4 | 69 | 53 | 76.8 | 80 | 59 | 73.8 | 93 | 67 | 72 | 412 | 256 | 62.1 | 0.803 |
CTX | 41 | 23 | 56.1 | 89 | 46 | 51.7 | 80 | 66 | 82.5 | 100 | 79 | 79 | 157 | 129 | 82.2 | 467 | 343 | 73.4 | 0.548 |
CZM | 49 | 24 | 49 | 102 | 56 | 54.9 | 83 | 62 | 74.7 | 81 | 66 | 81.5 | 107 | 93 | 86.9 | 422 | 301 | 71.3 | 0.409 |
CPM | 88 | 45 | 51.1 | 128 | 72 | 56.3 | 80 | 79 | 98.8 | 122 | 114 | 93.4 | 151 | 126 | 83.4 | 569 | 436 | 76.6 | 0.791 |
IPM | 132 | 69 | 52.3 | 130 | 80 | 61.5 | 85 | 81 | 95.3 | 120 | 105 | 87.5 | 180 | 154 | 85.6 | 647 | 489 | 75.6 | 0.171 |
MPM | 141 | 75 | 53.2 | 131 | 82 | 62.6 | 84 | 80 | 95.2 | 119 | 105 | 88.2 | 221 | 161 | 72.9 | 696 | 503 | 72.3 | 0.596 |
PIP-TZP | 120 | 60 | 50 | 110 | 67 | 60.9 | 78 | 61 | 78.2 | 121 | 116 | 95.9 | 160 | 135 | 84.4 | 589 | 439 | 74.5 | 0.180 |
TMP-SMZ | 128 | 65 | 50.8 | 122 | 73 | 59.8 | 79 | 63 | 79.7 | 118 | 101 | 85.6 | 174 | 144 | 82.8 | 621 | 446 | 71.8 | 0.378 |
GMN | 100 | 59 | 59 | 112 | 61 | 54.5 | 80 | 66 | 82.5 | 122 | 101 | 82.8 | 188 | 154 | 81.9 | 602 | 441 | 73.3 | 0.417 |
ACN | 160 | 85 | 53.1 | 125 | 75 | 60 | 81 | 70 | 86.4 | 123 | 114 | 92.7 | 229 | 160 | 69.9 | 718 | 504 | 70.2 | 0.666 |
CIP | 134 | 77 | 57.5 | 130 | 81 | 62.3 | 84 | 69 | 82.1 | 123 | 117 | 95.1 | 189 | 149 | 78.8 | 660 | 493 | 74.7 | 0.428 |
OXN | 130 | 72 | 55.4 | 133 | 96 | 72.2 | 84 | 60 | 71.4 | 115 | 96 | 83.5 | 153 | 131 | 85.6 | 615 | 455 | 74 | 0.868 |
LVX | 60 | 33 | 55 | 98 | 48 | 49 | 67 | 57 | 85.1 | 94 | 81 | 86.2 | 147 | 116 | 78.9 | 466 | 335 | 71.9 | 0.166 |
NFT | 63 | 26 | 41.3 | 91 | 76 | 83.5 | 81 | 63 | 77.8 | 88 | 54 | 61.4 | 151 | 118 | 78.1 | 474 | 337 | 71.1 | 0.430 |
TGN | 149 | 136 | 91.3 | 127 | 120 | 94.5 | 83 | 80 | 96.4 | 114 | 110 | 96.5 | 288 | 278 | 96.5 | 761 | 724 | 95.1 | 0.180 |
CLN | 143 | 122 | 85.3 | 130 | 123 | 94.6 | 76 | 71 | 93.4 | 116 | 111 | 95.7 | 280 | 279 | 99.6 | 745 | 706 | 94.8 | 0.370 |
Overall | 2015 | 2016 | 2017 | 2018 | 2019 | Total | P-value* | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(N = 5,316 isolates) | (N = 4,705 isolates) | (N = 5,019 isolates) | (N = 5,696 isolates) | (N = 7,018 isolates) | (N = 27,754 isolates) | ||||||||||||||
T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | T | S | S% | ||
AMP | 1977 | 1170 | 59.2 | 2178 | 1361 | 62.5 | 2166 | 1370 | 63.3 | 2755 | 2234 | 81.1 | 3466 | 2835 | 81.8 | 12,542 | 8970 | 71.5 | 0.683 |
AMX/CLA | 3334 | 2698 | 80.9 | 3244 | 2658 | 81.9 | 3799 | 3220 | 84.8 | 4246 | 3603 | 84.9 | 5260 | 4298 | 81.7 | 19,883 | 16,477 | 82.9 | 0.976 |
CZN | 819 | 350 | 42.7 | 1999 | 1411 | 70.6 | 1921 | 1276 | 66.4 | 2271 | 1596 | 70.3 | 3485 | 2520 | 72.3 | 10,495 | 7153 | 68.2 | 0.375 |
CRX | 1958 | 1078 | 55.1 | 2132 | 1256 | 58.9 | 1618 | 1003 | 62 | 2206 | 1568 | 71.1 | 3817 | 2568 | 67.3 | 11,731 | 7473 | 63.7 | 0.662 |
CFX | 2999 | 1390 | 46.3 | 1679 | 1092 | 65 | 1952 | 1095 | 56.1 | 2184 | 1635 | 74.9 | 2304 | 1414 | 61.4 | 11,118 | 6626 | 59.6 | 0.961 |
CTM | 928 | 443 | 47.7 | 960 | 529 | 55.1 | 1139 | 569 | 50 | 1345 | 701 | 52.1 | 1547 | 690 | 44.6 | 5919 | 2932 | 49.5 | 0.911 |
CTX | 3829 | 2736 | 71.5 | 3433 | 2826 | 82.3 | 3185 | 2699 | 84.7 | 4001 | 3366 | 84.1 | 5724 | 4319 | 75.5 | 20,172 | 15,946 | 79.1 | 0.975 |
CZM | 3682 | 2217 | 60.2 | 2565 | 2055 | 80.1 | 3604 | 2231 | 61.9 | 3178 | 2340 | 73.6 | 3573 | 2598 | 72.7 | 16,602 | 11,441 | 68.9 | 0.998 |
CPM | 2696 | 1706 | 63.3 | 3584 | 3077 | 85.9 | 3988 | 3288 | 82.4 | 4503 | 3755 | 83.4 | 5310 | 4527 | 85.3 | 20,081 | 16,353 | 81.4 | 0.866 |
IPM | 4693 | 3962 | 84.4 | 4347 | 3746 | 86.2 | 4614 | 4315 | 93.5 | 5357 | 5155 | 96.2 | 6738 | 6221 | 92.3 | 25,749 | 23,399 | 90.9 | 0.965 |
MPM | 4511 | 3949 | 87.5 | 4400 | 3880 | 88.2 | 4538 | 4326 | 95.3 | 5388 | 5113 | 94.9 | 6814 | 6270 | 92 | 25,651 | 23,538 | 91.8 | 0.966 |
PIP-TZP | 4347 | 3722 | 85.6 | 4266 | 3742 | 87.7 | 4561 | 4066 | 89.1 | 5197 | 4793 | 92.2 | 6255 | 5536 | 88.5 | 24,626 | 21,859 | 88.8 | 0.981 |
TMP-SMZ | 3337 | 2353 | 70.5 | 3707 | 2838 | 76.6 | 3630 | 2816 | 77.6 | 4219 | 3516 | 83.3 | 5475 | 4611 | 84.2 | 20,368 | 16,134 | 79.2 | 0.869 |
GMN | 4635 | 3808 | 82.2 | 4380 | 3922 | 89.5 | 4525 | 4079 | 90.1 | 5339 | 4875 | 91.3 | 6627 | 5929 | 89.5 | 25,506 | 22,613 | 88.7 | 0.967 |
ACN | 4740 | 3913 | 82.6 | 4484 | 4235 | 94.4 | 4637 | 4423 | 95.4 | 5426 | 5156 | 95 | 6830 | 6513 | 95.4 | 26,117 | 24,240 | 92.8 | 0.960 |
CIP | 4043 | 3208 | 79.3 | 3954 | 3374 | 85.3 | 3919 | 3556 | 90.7 | 5119 | 4211 | 82.3 | 5524 | 4908 | 88.8 | 22,559 | 19,257 | 85.4 | 0.971 |
OXN | 1861 | 1186 | 63.7 | 1961 | 1424 | 72.6 | 1777 | 1274 | 71.7 | 2023 | 1548 | 76.5 | 2611 | 1703 | 65.2 | 10,233 | 7135 | 69.7 | 0.985 |
LVX | 2362 | 1716 | 72.7 | 2560 | 1809 | 70.7 | 1863 | 1278 | 68.6 | 2679 | 1976 | 73.8 | 3540 | 2749 | 77.7 | 13,004 | 9528 | 73.3 | 0.847 |
NFT | 2403 | 1647 | 68.5 | 3780 | 3039 | 80.4 | 3924 | 3330 | 84.9 | 4359 | 3698 | 84.8 | 5428 | 4868 | 89.7 | 19,894 | 16,582 | 83.4 | 0.921 |
TGN | 4184 | 3782 | 90.4 | 3882 | 3671 | 94.6 | 3962 | 3767 | 95.1 | 4546 | 4490 | 98.8 | 6291 | 6022 | 95.7 | 22,865 | 21,732 | 95 | 0.968 |
CLN | 3265 | 2859 | 87.6 | 2912 | 2462 | 84.5 | 2961 | 2688 | 90.8 | 3224 | 2175 | 67.5 | 6124 | 5887 | 96.1 | 18,486 | 16,071 | 86.9 | 0.608 |
N number of pathogens causing healthcare-associated infections, T number of tested isolates, S number of susceptible pathogens, S (%) percentage of susceptible pathogens, AMP ampicillin, AMX/CLA amoxicillin/clavulanic acid, CZN cefazolin, CRX cefuroxime, CFX cefixime, CTM cefotaxime, CTX ceftriaxone, CZM ceftazidime, CPM cefepime, IPM imipenem, MPM meropenem, PIP-TZP piperacillin/tazobactam, TMP-SMZ trimethoprim-sulfamethoxazole, GMN gentamicin, ACN amikacin, CIP ciprofloxacin, OXN ofloxacin, LVX levofloxacin, NFT nitrofurantoin, TGN tigecycline, CLN colistin
*Multivariate analysis of variance (MANOVA) for resistance trend