. 2021 Jun 12;13:142. doi: 10.1007/s40820-021-00630-6

Table 1.

Lung cancer types, sub-types and featured receptors

Lung cancer type	Sub-type	Featured upregulated receptors
Non-small cell lung cancer (NSCLC) (80–85%)	Adenocarcinoma Major form of NSCLC orginating from mucus-secreting cells of peripheral lung tissue with slow progression Squamous cell carcinoma Originates from airway lining of pleural cells Large cell carcinoma Cancer originating from central part od the lungs, often of neuroendocrine origin, aggressive and advanced at diagnosis	Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2/neu), folate receptor alpha (FRα), TNF-related apoptosis-inducing ligand (TRAIL) death receptors DR4 & DR5, tetraspanins CD151, mesenchymal–epithelial transition (MET), estrogen receptors (ERα and ERβ), G-protein-coupled estrogen receptors, progesterone receptors (PRA and PRB), peroxisome proliferator-activated receptor gamma (PPARγ), somatostatin, neuropilins receptor proteins (NRP), echinoderm microtubule-associated protein like 4 anaplastic lymphoma kinase (EML4-ALK), vascular endothelial growth factor receptor (VEGFR), cluster differentiation 44 (CD44), bombesin receptors (BBR1, BBR2, and BBR3), oxytocin and vasopressin receptors
SCLC (10–15%)	Smoking is the major cause, is neuroendocrine in origin, often non-resectable, metastatic and with high relapse rates	Epidermal growth factor receptor (EGFR), somatostatin, CD24, bombesin receptors (BBR1, BBR2, and BBR3), bradykinin receptors, oxytocin and vasopressin receptors, insulin-like growth factor 1 receptor, fibroblast growth factor receptors
Others (~ 5%)	Pleural mesothelioma Lung carcinoid tumors Hamartomas Adenoid cystic carcinoma Adenoid cystic lymphoma Adenoid cystic sarcoma	Epidermal growth factor receptor (EGFR), folate receptor alpha (FRα), cluster differentiation 44 (CD44), interleukin 4 receptor alpha, estrogen receptor (ERβ)

Lung cancer type

Sub-type

Featured upregulated receptors

Non-small cell lung cancer (NSCLC) (80–85%)

Adenocarcinoma Major form of NSCLC orginating from mucus-secreting cells of peripheral lung tissue with slow progression

Squamous cell carcinoma Originates from airway lining of pleural cells

Large cell carcinoma Cancer originating from central part od the lungs, often of neuroendocrine origin, aggressive and advanced at diagnosis

Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2/neu), folate receptor alpha (FRα), TNF-related apoptosis-inducing ligand (TRAIL) death receptors DR4 & DR5, tetraspanins CD151, mesenchymal–epithelial transition (MET), estrogen receptors (ERα and ERβ), G-protein-coupled estrogen receptors, progesterone receptors (PRA and PRB), peroxisome proliferator-activated receptor gamma (PPARγ), somatostatin, neuropilins receptor proteins (NRP), echinoderm microtubule-associated protein like 4 anaplastic lymphoma kinase (EML4-ALK), vascular endothelial growth factor receptor (VEGFR), cluster differentiation 44 (CD44), bombesin receptors (BBR1, BBR2, and BBR3), oxytocin and vasopressin receptors

SCLC (10–15%)

Smoking is the major cause, is neuroendocrine in origin, often non-resectable, metastatic and with high relapse rates

Epidermal growth factor receptor (EGFR), somatostatin, CD24, bombesin receptors (BBR1, BBR2, and BBR3), bradykinin receptors, oxytocin and vasopressin receptors, insulin-like growth factor 1 receptor, fibroblast growth factor receptors

Others (~ 5%)

Pleural mesothelioma

Lung carcinoid tumors

Hamartomas

Adenoid cystic carcinoma

Adenoid cystic lymphoma

Adenoid cystic sarcoma

Epidermal growth factor receptor (EGFR), folate receptor alpha (FRα), cluster differentiation 44 (CD44), interleukin 4 receptor alpha, estrogen receptor (ERβ)