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. 2021 May 23;22(11):5501. doi: 10.3390/ijms22115501

Figure 8.

Figure 8

In vivo antitumor activity of JVM-PE24X7. Mice bearing C4-2B tumors were treated with the immunotoxin JVM-PE24X7 or PBS on days 1, 4, 7, 10 and 13. (A) Changes in tumor volume and (B) body weight in the mice were measured every other day. Arrows indicate the time points of JVM-PE24X7 injection. (C) Histological analysis of the tumor and major tissues after treatment with PBS and JVM-PE24X7 (400×). Scale bar: 100 μm. Error bars, means ± SEM (n = 5). Statistical significance was calculated by Student’s t-test: * p < 0.05; **** p < 0.0001.