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. 2021 May 24;10(11):2259. doi: 10.3390/jcm10112259

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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miRNAs are significantly regulated in only metastasis-derived melanoma cell lines. (A) miRNAs that are not regulated in MBrCs vs. NHEMs (p > 0.05) and only significantly differentially expressed (p < 0.05) in MBrCs vs. melanoma metastasis-derived (MET) cell lines with log2fold in MET vs. PT > 1 or < −1 and in MBrC vs. PT > −1 and simultaneously < 1. Mentions in the literature of functional relevance of the respective miRNA in melanoma or other cancers are indicated (+). (B) Venn diagram of shared predicted targets of upregulated miR-4426, miR-203a-3p, and miR-4516. (C) Venn diagram of shared predicted targets of downregulated miR-20b-3p, miR-363-3p, and miR-211-5p. (D) STRING network analysis of connected target genes of the 51 shared targets of miR-20b-3p, miR-363-3p, and miR-211-5p (blue) and additionally involved genes (grey).