Table 2.

Univariate Cox proportional hazards model.

		Overall Survival		Merkel Cell Carcinoma-Specific Survival		Progression-Free Survival
	N	Hazard Ratio	p-Value	Hazard Ratio	p-Value	Hazard Ratio	p-Value
PD-L1 >1%	132	0.55	0.016 *	0.41	0.019 *	0.56	0.043 *
CD8-high	132	0.76	0.25	0.45	0.036 *	0.62	0.098
FoxP3-high	132	0.66	0.092	0.62	0.17	0.57	0.047 *
IDO1-high	130	0.93	0.75	1.15	0.69	1.29	0.36
CD8-high FoxP3-high	132	0.66	0.13	0.41	0.046 *	0.58	0.091
PD-L1 >1% FoxP3-high	132	0.43	0.0072 *	0.28	0.017 *	0.35	0.004 *
PD-L1 >1% CD8-high	132	0.57	0.053	0.28	0.018 *	0.45	0.024 *
PD-L1 >1% IDO1-high	130	0.50	0.057	0.87	0.74	1.14	0.66
Size (>20 mm)	132	1.03	0.91	1.31	0.44	1.20	0.50
Thickness (>10 mm)	132	1.04	0.89	1.14	0.71	1.06	0.84
Growth pattern (nodular versus infiltrative/mixed)	132	0.69	0.12	0.58	0.12	0.57	0.051
Ulceration	132	2.01	0.0046 *	2.51	0.008 *	1.67	0.067
Mitoses (>40/mm2)	132	0.97	0.89	1.28	0.47	1.17	0.58
Necrosis	132	1.30	0.32	1.19	0.66	1.45	0.19
Lymphovascular invasion	132	1.50	0.095	2.29	0.02 *	1.51	0.14
MCPyV large T-antigen	132	0.52	0.0076 *	0.49	0.04 *	0.71	0.22
Age (>versus ≤77 years)	132	2.35	0.00067 *	1.33	0.41	0.9	0.7
Gender (male versus female)	132	1.29	0.28	2.23	0.029 *	2.29	0.006 *
Site (other versus head & neck)	132	1.32	0.26	0.76	0.44	0.48	0.012 *
Stage (3–4 versus 1–2)	132	1.27	0.62	2.75	0.038 *	27.2	<0.0001 *
Immunosuppression	132	1.18	0.63	1.2	0.71	1.02	0.97
Treatment (adjuvant therapy versus surgery	132	1.13	0.63	1.82	0.094	1.52	0.13

MCPyV: Merkel cell polyomavirus. * p < 0.05, statistically significant; p < 0.09, approaching statistical significance.