Table 3.
Multivariate Cox proportional hazards model.
| Overall Survival | Merkel Cell Carcinoma-Specific Survival | Progression-Free Survival | |||||
|---|---|---|---|---|---|---|---|
| N | Hazard Ratio | p-Value | Hazard Ratio | p-Value | Hazard Ratio | p-Value | |
| PD-L1 >1% | 132 | 0.92 | 0.78 | 0.84 | 0.76 | 1.48 | 0.37 |
| Ulceration | 132 | 1.79 | 0.03 * | 1.73 | 0.18 | - | - |
| MCPyV T-antigen expression | 132 | 0.73 | 0.24 | 0.72 | 0.41 | - | - |
| PD-L1 >1% FoxP3-high | 132 | 0.54 | 0.13 | 0.99 | 0.99 | 0.32 | 0.058 |
| PD-L1 >1% CD8-high | 132 | - | - | 0.27 | 0.15 | 0.70 | 0.48 |
| CD8-high FoxP3-high | 132 | - | - | 0.44 | 0.26 | - | - |
| Lymphovascular invasion | 132 | - | - | 1.94 | 0.1 | - | - |
| CD8 | 132 | - | - | 2.4 | 0.24 | - | - |
| FoxP3 | 132 | - | - | - | - | 1.35 | 0.41 |
| Age | 132 | 2.13 | 0.0031 * | - | - | - | - |
| Gender | 132 | - | - | 1.78 | 0.19 | 2.08 | 0.018 * |
| Site (other versus head & neck) | 132 | - | - | - | - | 0.56 | 0.064 |
| Stage (3–4 versus 1–2) | 132 | - | - | 2.37 | 0.12 | 20.57 | <0.0001 * |
MCPyV: Merkel cell polyomavirus. * p < 0.05, statistically significant; p < 0.09, approaching statistical significance.