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. 2021 May 23;13(11):2559. doi: 10.3390/cancers13112559

Figure 3.

Figure 3

Association between thermogenesis (low/high) and intratumoral heterogeneity, homologous recombination defects (HRDs), mutations, adipocytes, the expression of vessel-related cells, blood endothelial cell markers, and vascular-stability-related genes in the TCGA, METABRIC and GSE96058 cohorts. (A) Intratumoral heterogeneity, homologous recombination defects, and mutation-related scores, including mutation rate, fraction altered, single nucleotide variants (SNVs) and indel neoantigens along with proliferation score. (B) Abundance of adipocytes in high-thermogenesis TNBC. (C) High-thermogenesis TNBC with an abundance of vessel-related cells (endothelial cells, microvascular endothelial cells, and lymphatic endothelial cells). (D) High-thermogenesis TNBC showing higher gene expression level of endothelial cell marker-related genes CD31 (PECAM1) and von-Willebrand factor (vWF). (E) High-thermogenesis TNBC showing higher gene expression levels of vascular-stability-related genes VE-cadherin, Claudin 5, JAM2, and sphingosine-1-phosphate-related gene (S1PR1). (F) Abundance of pericytes. One-way ANOVA test was used to calculate p-values.