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. 2021 May 24;13(11):2570. doi: 10.3390/cancers13112570

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PARP inhibitor resensitized cells with high expression of MGMT to TMZ. (A) Western blot analysis of MGMT and β-actin levels in SF767 cells. U251 was used as negative control for MGMT expression. (B) Colony formation efficiency of SF767 cells following talazoparib (2.5 nM, 4 days), and/or TMZ (100 μM, 3 h). (C) Fluorescence-activated cell sorting analysis of cell cycle distribution in SF767 cells after talazoparib and/or TMZ exposure. (D) Western blot analysis of cleaved PARP and β-actin levels in SF767 cells treated with talazoparib and/or TMZ. *, p < 0.05.