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Like ADA1, ADA2 is involved in the conversion of adenosine into inosine. On one hand, a deficit of ADA1 protein is responsible for the development of severe combined immunodeficiency (SCID), on the other hand, ADA2 deficiency is associated with reduction of M2 macrophages and polarization towards M1 macrophages, with consequent increased production of proinflammatory cytokines and endothelium damage and fibrosis, and DADA2 disease. Figure adapted from [87].
