Table 1.

Medications for immune-mediated brain diseases.

Target	Medications	Monogenic Disorders (Key Neurological Symptoms)	Multifactorial Disorders
Type I IFN	JAK inhibitors (baricitinib, ruxolitinib, tofacitinib), antimalarials	Type I interferonopathies (seizures, leukodystrophy, headaches)	SLE
TNFα	Etanercept, adalimumab, infliximab	DADA2 vasculitis, strokes	Neuro-BD
IL-1 receptor	Anakinra	CAPS, aseptic meningitis, pseudotumor cerebri	FIRES

Legend: IFN, interferon; SLE, systemic lupus erythematosus; TNFα, tumor necrosis factor-α; DADA2, deficiency of adenosine deaminase 2; BD, Behçet’s disease; IL-1, interleukin-1; CAPS, cryopyrin-associated autoinflammatory syndrome; FIRES, febrile infection-related epilepsy syndrome.