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. 2021 May 24;18(11):5588. doi: 10.3390/ijerph18115588

Figure 1.

Figure 1

Brain and spine MRI at diagnosis of MS. Legend: the figure shows four MRI sequences (A–D). Explanation below. (A) Axial T2-weighted using a fluid attenuated inversion recovery (FLAIR), sequences of the brain MRI show typical periventricular hyperintense lesions due to the demyelination of the white matter. (B) The hyperintense lesions observed in sequence A appear hypointense in axial T1-weighted sequences of the brain MRI, due to axonal destruction and irreversible damage (also called “black holes”). (C) Sagittal T2-weighted using a fluid attenuated inversion recovery (FLAIR), sequences of the brain MRI show periventricular hyperintense lesions along the axis of the medullary veins, perpendicular to the body of the lateral ventricles and of the callosal junction (also called “Dawson’s fingers”). (D) Sagittal T2-weighted sequences of the spine MRI show a hyperintense demyelinating lesion at C3 level.