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. 2021 May 24;10(11):2265. doi: 10.3390/jcm10112265

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The age at onset and course of visual acuity findings are shown for the 3 phenotypes. (A) The graph shows the age at onset in patients with autosomal dominant (AD)-retinitis pigmentosa (RP), autosomal recessive (AR)-RP, and AR-cone dystrophy (COD)/cone-rod dystrophy (CORD). The age at onset significantly differed between patients with AR-RP and AD-RP (p < 0.001, Bonferroni test) and between patients with AR-RP and AR-COD/CORD (p < 0.001), but not between patients with AD-RP and AR-COD/CORD (p = 0.508). The asterisks indicate statistical significance (p-values < 0.05). (B) The graph shows the course of visual acuity in patients with AR-RP (in blue), AD-RP (in orange), and AR-COD/CORD (in green). Visual acuity starts to worsen in patients with AR-RP around their 20s and reaches severe visual dysfunction by their 40s; in contrast, good visual acuity is preserved in patients with AD-RP until their 50–60s. Furthermore, visual acuity shows a tendency toward relative preservation in patients with AR-COD/CORD until their 50s, with subsequent deterioration and progressive macular atrophy.