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Synthesis of desired amides 25a–d and 26a. Reagents and conditions: (a) CrO3, H2SO4, acetone, H2O; (b) NaClO2, KH2PO4, DMSO, H2O, r.t.; (c) NaClO2, KH2PO4, H2O2, CH3CN, H2O, r.t.; (d) SOCl2, benzene, Δ; (e) toluene, Et3N, r.t.; (f) T3P, Py, EtOAc (r.t. for 25a,b, reflux for 25c,d); (g) 1-aminoadamantane, T3P, Py, EtOAc, r.t.
