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The water-soluble matrix (WSM) was extracted from pearl powder and size-fractionated using a 14 kDa cut-off dialysis tubing to give >14 kDa retentate (MR14), followed by a 3 kDa tubing dialysis to give 3–14 kDa retentate (MR3-14) and <3 kDa retentate (MR3). Effects of WSM, MR14, MR3–14, and MR3 on the growth of fibroblasts (μg/mL): incubation (A) after 2 days and (B) after 3 days. Reproduced from [49]. * p < 0.05; ** p < 0.01; **** p < 0.005.
