. 2021 May 24;13(11):2576. doi: 10.3390/cancers13112576

Table 5.

Summary of multivariable regression analyses in FACT- Cog total scores, FACT- PCI, FACT- PCA, SFT among the three groups.

Predictors	Non cancer (n = 30)						Pre-C/T (n = 68)						Post-C/T (n = 35)
Predictors	β	R²	ΔR²	p-Value	Confidence Interval (CI)		β	R²	ΔR²	p-Value	CI	β	R²	ΔR²	p-Value	CI
FACT-Cog		0.599	0.099	0.012				0.155	0168	0.001	0.33~1.19		0.429	0.212	0.001
Age												−0.43			0.001	−0.68~−0.18
HADS	−2.08			0.012	−3.68~	−0.49
PHQ-9												−1.48			0.001	−2.27~−0.68
BFI_interference	−7.01			<0.001	−10.16~	−3.85	−0.73				−1.13~−0.33
FACT-PCI		0.569	0.084	0.025				0.334	0.058	0.019			0.397	0.078	0.044
Age							0.16			0.011	0.04~0.27	−0.22			0.007	−0.37~−0.06
BMI												−0.40			0.044	−0.78~−0.01
PHQ-9							−0.40			0.019	−0.72~−0.07	−0.71			0.008	−1.23~−0.20
BFI_interference	−4.83			<0.001	−6.63~	−3.03	−0.36			0.005	−0.61~−0.11
Log IL-5	−7.98			0.025	−14.87~	−1.08	−0.73				−1.13~−0.33
FACT-PCA		0.443	0.115	0.021				0.227	0.069	0.017			0.340	0.144	0.010
Age												−0.17			0.001	−0.27~−0.08
IQ							0.01			0.005	0.03~0.17
PHQ							−0.23			0.017	−0.41~−0.04
HADS	−0.76			0.010	−1.32~	−0.02						−0.51			0.010	−0.89~−0.13
BFI_interference	−1.32			0.021	−2.43~	−0.21
Log IL-10	3.88			0.011	0.97~	6.79	3.66			0.002	1.43~5.89
Log IL-13							−2.28			0.008	−3.95~−0.62
SFT		0.218	0.245	0.005				0.144	0157	0.001			0.458	0.077	0.036
Years of education	1.02				0.32~	1.72	0.76				0.33~1.19
IQ												0.27			0.002	0.11~0.44
HADS-A												1.87			0.001	0.86~2.87
PHQ-9												−0.90			0.036	−1.73~−0.06
Log IL-13												−4.94			0.008	−8.46~−1.42

Multivariate stepwise regression adding all variables (including cytokines) into the model. FACT-Cog: Functional Assessment of Cancer Therapy Cognitive Function; FACT-PCI: Perceived Cognitive Impairment; FACT-PCA: Perceived Cognitive Abilities; β: standardized regression coefficients; R² = R square; ΔR² = R square change.