Table 8.
Literature with respect to receptors and pathways.
| Collagen Source | Receptor/Proteins/Complex | Activated Pathway | Associated Receptors with Activation of Pathway | Resulting Factors (Anti-Bacterial, Antimicrobial, Anti-Oxidation) |
Biomedical Effect |
|---|---|---|---|---|---|
| Prolyl-hydroxyproline (Pro-Hyp) [160] | p75NTR | - | - | - | Wound healing |
| Porcine collagen [19] | PTEN, CDK-2, CDK-4 |
PI3K/AKT | Cell proliferation, anti-apoptosis |
||
| Salmo salar skin collagen peptides (Ss-SCPs) and Tilapia nilotica skin collagen peptides [25] | pattern recognition receptor (NOD2) | NF-κB signal pathway | Toll-like receptors (TLRs) | BD14 (modulation through upregulation/down regulation/null) | Wound healing |
| Chum Salmon skin hydrolysate [172] | TGF-β | Smad | TGF-β type II receptors (TβRII) | Type I and III mRNA, TGF-βRII |
Skin cellular homeostasis |
| Porcine bone collagen peptide [20] | Runx2 | MAPK | - | - | Osteoblast |
| β-Catenin | Wnt/β-catenin | - | - | ||
| Fish collagen hydrolysate [173] | IL-1β | ERK and p38 | - | MMP13 | Osteoarthritis |