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. 2021 May 25;13(11):2586. doi: 10.3390/cancers13112586

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Different enrichments of CNA facilitator genes for amplification/insertion CNA and for deletion CNA (A) IPA for amplification/insertion CNA facilitator genes. Replication stress-inducing genes and pathways (e.g., Role of BRCA1 in DNA Damage Response) are enriched. (B) IPA for deletion CNA facilitator genes. Kinetochore Metaphase signaling pathway is shown. Purple highlighting indicates particular genes with significant GE-CNA correlations and/or a cluster of such genes in the IPA pathways.

Different enrichments of CNA facilitator genes for amplification/insertion CNA and for deletion CNA (A) IPA for amplification/insertion CNA facilitator genes. Replication stress-inducing genes and pathways (e.g., Role of BRCA1 in DNA Damage Response) are enriched. (B) IPA for deletion CNA facilitator genes. Kinetochore Metaphase signaling pathway is shown. Purple highlighting indicates particular genes with significant GE-CNA correlations and/or a cluster of such genes in the IPA pathways.