Table 1.
Adiponectin receptor agonists related findings in cancer models.
| Agonist | Cancer Type | Cell Line | Anticancer Action | Pathway | Reference |
|---|---|---|---|---|---|
| AdipoRon | PDAC | Panc-1, Mia Paca-2 (human) Panc.02, P-4313, K-8484 (mouse) |
Apoptosis | STAT3 ACC |
[53] |
| AsPC-1, Mia Paca-2, BxPC-3, Panc-1 (human) | G0/G1 Blockage Necroptosis |
AKT ERK1/2 p38 AMPK |
[60] | ||
| Ovarian | OVCAR3, OVCAR4, A2780 (human) | G0/G1 Blockage Apoptosis |
AMPK | [54] | |
| Myeloma | Sp2/0-Ag14 and MPC-11 (mouse) | Apoptosis Autophagy |
AMPK ACC |
[55] | |
| TNBC | MDA-MB-468, MDA-MB-231, LM2 (human) | n/a | n/a | [56] | |
| Osteosarcoma | U2OS, MG-63, Saos-2 (human) | G0/G1 Blockage | ERK1/2 | [62] | |
| ADP355 | Prostate | LNCaP (human) | n/a | AMPK mTOR p53 |
[82] |
| TNBC | MCF7, MDA-MB-231 (human) | n/a | AMPK ERK1/2 STAT3 |
[81,83] | |
| Myeloid | K562 (human) | n/a | n/a | [83] | |
| Glioma | LM18 (human) | n/a | STAT3 AKT |
[81] |
(n/a) Not Available.