Table 4.
Clinical and Immunological Factors with INH Status and Cumulative TB Incidence in HIV Infected Individuals in Northwest Ethiopia, September 11, 2008 to March, 2015, N = 391
| Clinical Variables | INH Completed | Never on INH | |||
|---|---|---|---|---|---|
| TB (%) | Total | TB (%) | Total | ||
| WHO stage | |||||
| Stage I | 1(1.6) | 63.0 | 2(3.4) | 58.0 | |
| Stage II | 0(0.0) | 45.0 | 2(4.1) | 47.0 | |
| Stage III | 1(1.2) | 74.0 | 23(29.5) | 78.0 | |
| Stage IV | 0(0.0) | 5.00 | 9(69.2) | 13.0 | |
| Previous TB rx | |||||
| Yes | 0(0.0) | 23.0 | 6(27.3) | 22.0 | |
| No | 2(1.2) | 170 | 30(17.0) | 176 | |
| B. functional sta. | |||||
| Working | 2(1.3) | 155 | 21(13.4) | 157 | |
| Ambulatory & Bed. | 0(0.0) | 38.0 | 15(36.6) | 41.0 | |
| Baseline BMI | |||||
| <18.5 kg/m2 | 1(1.6) | 64.0 | 22(25.3) | 87.0 | |
| ≥18.5 kg/m2 | 1(0.8) | 129 | 14(12.6) | 111 | |
| Baseline Hgb. | |||||
| <10 mg/dl | 0(0.0) | 5.00 | 1(11.1) | 9.00 | |
| 10–12 mg/dl | 0(0.0) | 26.0 | 21(25.6) | 53.0 | |
| >12 mg/dl | 2(1.2) | 162 | 24(16.4) | 146 | |
| Baseline CD4 | |||||
| ≤100 cells/μL | 0(0.0) | 35.0 | 14(30.4) | 56.0 | |
| 101–200 cells/μL | 0(0.0) | 49.0 | 6(10.5) | 57.0 | |
| 201–350 cells/μL | 0(0.0) | 50.0 | 11(23.4) | 47.0 | |
| >350 cells/μL | 2(3.4) | 59.0 | 5(10.4) | 48.0 | |
| CD4 at ART in. | |||||
| ≤100 cells/μL | 0(0.0) | 35.0 | 3(8.1) | 37.0 | |
| 101–200 cells/μL | 0(0.0) | 68.0 | 1(1.6) | 61.0 | |
| 201–350 cells/μL | 0(0.0) | 51.0 | 2(5.1) | 39.0 | |
| >350 cells/μL | 0(0.0) | 18.0 | 2(7.4) | 27.0 | |
| ART status | |||||
| On ART | 0(0.0) | 172 | 8(4.9) | 164 | |
| On Pre-ART | 2(9.5) | 21.0 | 28(82.4) | 34.0 | |
| Duration of ART | |||||
| < 2 years | 0(0.0) | 27.0 | 6(18.8) | 32.0 | |
| 2–3 years | 0(0.0) | 18.0 | 1(0.8) | 118 | |
| >3 years | 0(0.0) | 127 | 1(7.1) | 14.0 | |
| Past OIs other than TB | |||||
| Yes | 0(0.0) | 80.0 | 19(19.8) | 96.0 | |
| No | 2(1.8) | 113 | 17(16.7) | 102 | |
| CPT initiation | |||||
| Yes | 0(0.0) | 167 | 30(17.8) | 169 | |
| No | 2(7.7) | 25.0 | 6(20.7) | 29.0 | |
Abbreviations: TB rx hx, tuberculosis treatment history; sta, status; BMI, body mass index; Hgb, hemoglobin; CPT, cotrimoxazole preventive therapy; OIs, opportunistic infections; μL, micro litters; mg/dl, milligram per deciliter.