Table 5.
Bi Variable and Multivariable Cox Hazard Regression Analysis for Socio Demographic, Clinical and Immunological Factors with TB Incidence Among HIV Infected Individuals in Northwest Ethiopia from September 11, 2008 to March, 2015, N = 391
| Variables | Outcome Status | ||||
|---|---|---|---|---|---|
| TB (%) | Total | IR/100PY | CHR (95% CI) | AHR (95% CI) | |
| Age | |||||
| 18–29 | 11(7.6) | 145 | 2.67 | 0.41[0.15,1.11] | 1.41[0.43,4.64] |
| 30–39 | 14(9.5) | 148 | 3.39 | 0.52[0.20,1.35] | 1.83[0.66,5.09] |
| 40–49 | 7(11.1) | 63.0 | 4.08 | 0.62[0.21,1.80] | 1.38[0.43,4.44] |
| ≥50 | 6(17.1) | 35.0 | 6.81 | 1 | 1 |
| Sex | |||||
| Male | 18(15.7) | 115 | 6.01 | 2.29[1.21,4.33]* | 1.98[0.97,4.07] |
| Female | 20(7.2) | 276 | 2.55 | 1 | 1 |
| Residence | |||||
| Rural | 9(16.7) | 54.0 | 6.60 | 2.10[0.99,4.44] | 1.02[0.38,2.70] |
| Urban | 29(8.6) | 337 | 3.06 | 1 | 1 |
| INH status | |||||
| Completed | 2(1.0) | 193 | 0.35 | 0.05[0.01,0.21]* | 0.08[0.02,0.37]* |
| Never on INH | 36(18.2) | 198 | 7.10 | 1 | 1 |
| ART status | |||||
| On ART | 8(2.4) | 336 | 0.81 | 0.03[0.01,0.07]* | 0.02[0.01,0.04]* |
| Pre-ART | 30(54.5) | 55.0 | 32.04 | 1 | 1 |
| B. WHO stage | |||||
| Stage I and II | 5(2.3) | 215 | 0.78 | 0.11[0.04,0.29]* | 0.22[0.08,0.62]* |
| Stage III and IV | 33(18.8) | 176 | 7.42 | 1 | 1 |
| B. Functional | |||||
| Ambula. & Be. | 15(19.0) | 78.0 | 7.61 | 2.79[1.46,5.35]* | 0.95[0.43,2.10] |
| Working | 23(7.4) | 312 | 2.59 | 1 | 1 |
| Baseline BMI | |||||
| <18.5 kg/m2 | 23(15.2) | 151 | 5.79 | 2.56[1.34,4.91]* | 1.90[0.24,15.21] |
| ≥18.5 kg/m2 | 15(6.3) | 238 | 2.18 | 1 | |
| BMI at start S. | |||||
| <18.5 kg/m2 | 22(19) | 116 | 7.52 | 3.53[1.86,6.73]* | 0.73[0.36,1.48] |
| ≥18.5 kg/m2 | 16(5.8) | 275 | 2.02 | 1 | 1 |
| Baseline CD4 | |||||
| ≤350 cells/μL | 31(10.9) | 284 | 4.02 | 1.76[0.78,7.24] | 3.76[1.39,10.18]* |
| >350 cells/μL | 7(6.5) | 107 | 2.24 | 1 | 1 |
| Duration of HI. | |||||
| <5 years | 37(14.9) | 249 | 5.60 | 22.8[3.12,165.9]* | 1.82[0.16,20.75] |
| ≥5 years | 1(0.7) | 142 | 0.24 | 1 | 1 |
Notes: *Statistically significant at P-value≤0.05 or one not included in CI, confidence interval; inf, infection; B. hemoglobin, baseline hemoglobin; B. functional status, baseline functional status; CHR, crude hazard ratio; AHR, adjusted hazard ratio; IR, incidence rate; PY, person years; ab, above; Dx, diagnosis; o & b, only and both; duration of HI, duration of HIV diagnosis, ART initi- initiation.