Table 3.
Population Parameter Estimates from the Final Model
| Parameter Estimate (RSE) | Interindividual Variability (RSE) | |
|---|---|---|
| Ka (h−1) | 0.498 (12.0) | NE |
| Tlag (h) | 0.15 (6.6) | NE |
| CL/F(L/h)=θ1+θ2*/weight/20 | θ1=120 (41.2) θ2=198 (18.9) |
38.9 (25.6) |
| Vc/F (L) | 118 (40.0) | 139.6(39) |
| CLd/F (L/h) | 210 (23.1) | NE |
| Vp/F (L) | 3730 (46.9) | NE |
| Residual error (ng/mL) | 0.16 (15.1) |
Note: Interpatient variability was expressed as coefficient of variation.
Abbreviations: Ka, first-order absorption rate constant; CL/F, total body clearance; Vc/F, apparent volume of distribution of the central compartment; CLd/F, apparent intercompartmental clearance; Vp/F, apparent volume of distribution of the peripheral compartment; Tlag, absorption lag time; RSE, residual standard error; NE, not estimated