Table 3.
Changes in the logistic regression model predicting diagnosis after adding covariates.
| LR χ2model | Pmodel | βIV | z IV | PIV | βcovariate | z covariate | Pcovariate | AUROC | PPV | NPV | % Dx | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T15 ΔMEP | 4.79 | 0.029 | –1.55 | –2.07 | 0.038 | – | – | – | 0.637 | 100.00% | 72.41% | 73.77% |
| T15 ΔMEP plus Education† | 4.94 | 0.084 | –1.32 | –1.75 | 0.081 | –0.18 | –1.32 | 0.187 | 0.644 | 100.00% | 78.43% | 80.36% |
| T15 ΔMEP plus Race | 8.13 | 0.017 | –1.31 | –1.74 | 0.081 | 1.15 | 1.75 | 0.080 | 0.704 | 88.89% | 78.85% | 80.33% |
| T15 ΔMEP plus BDNF ‡ | 6.04 | 0.049 | –1.76 | –2.11 | 0.034 | 0.53 | 0.85 | 0.397 | 0.635 | 100.00% | 75.51% | 77.78% |
| T15 ΔMEP plus APOE * | 7.16 | 0.028 | –2.13 | –2.41 | 0.016 | 0.20 | 0.31 | 0.756 | 0.699 | 100.00% | 75.51% | 77.36% |
| T15 ΔMEP plus Handedness | 5.54 | 0.063 | –1.58 | –2.09 | 0.036 | –0.94 | –0.88 | 0.379 | 0.647 | 100.00% | 75.00% | 77.05% |
| T15 ΔMEP plus IQ | 5.85 | 0.054 | –1.63 | –2.12 | 0.034 | –0.02 | –1.03 | 0.304 | 0.691 | 83.33% | 74.55% | 75.41% |
| T15 ΔMEP plus Age | 6.02 | 0.049 | –1.45 | –1.93 | 0.053 | 0.02 | 1.11 | 0.266 | 0.668 | 71.43% | 74.07% | 73.77% |
| T15 ΔMEP plus Sex | 5.41 | 0.067 | –1.42 | –1.86 | 0.063 | –0.65 | –0.76 | 0.447 | 0.664 | 100.00% | 72.41% | 73.77% |
| T15 ΔMEP plus Baseline MEP | 4.80 | 0.091 | –1.54 | –2.01 | 0.044 | 0.02 | 0.11 | 0.915 | 0.639 | 100.00% | 72.41% | 73.77% |
| T15 ΔMEP plus RMT | 4.79 | 0.091 | –1.54 | –2.00 | 0.045 | –0.001 | –0.03 | 0.976 | 0.639 | 100.00% | 72.41% | 73.77% |
| T15 ΔMEP plus AMT | 6.65 | 0.036 | –1.78 | –2.27 | 0.023 | 0.08 | 1.35 | 0.177 | 0.677 | 66.67% | 72.73% | 72.13% |
Models including a covariate are ranked based on their % Dx. Diagnosis was 0 for NT and 1 for ASD. IV refers to T15 ΔMEP. Sex was 0 for males and 1 for females. Race was 0 for White and 1 for non-White. Racial categories were defined according to the National Institutes of Health guidelines (NIH Office of Extramural Research, 2001). Handedness was for 0 for right-handed and 1 for left-handed. BDNF was 0 for Met− and 1 for Met+. APOE was 0 for ε4− and 1 for ε4+. Significant p-values are in bold font. % Dx, percentage correctly classified; AMT, active motor threshold; APOE, apolipoprotein E; ASD, autism spectrum disorder; AUROC, area under the receiver operating characteristic curve; BDNF, brain-derived neurotrophic factor; IQ, intelligence quotient; IV, independent variable; LR, likelihood ratio; ΔMEP, baseline-corrected, natural log-transformed amplitude of the motor evoked potential; Met, metionine; NPV, negative predictive value; NT, neurotypical; PPV, positivie predictive value; RMT, resting motor threshold; T15, 15 minutes post-cTBS.
APOE data were available for 16 and 39 participants in the ASD and NT groups, respectively.
Education data were available for 16 and 42 participants in the ASD and NT groups, respectively.
BDNF data were available for 17 and 39 participants in the ASD and NT groups, respectively.