Table 4.
The logistic regression models within BDNF and APOE subgroups.
| LR χ2model | Pmodel | βIV | z IV | PIV | βcovariate | z covariate | Pcovariate | AUROC | PPV | NPV | % Dx | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BDNF Met − (n = 31; 23 NT, 8 ASD) | ||||||||||||
| T15 ΔMEP | 0.50 | 0.480 | –1.0 | –0.69 | 0.490 | – | – | – | 0.571 | – | 73.33% | 73.33% |
| T15 ΔMEP plus Education† | 0.11 | 0.950 | 0.52 | 0.32 | 0.750 | –0.002 | –0.01 | 0.992 | 0.570 | – | 80.00% | 80.00% |
| T15 ΔMEP plus Race | 1.26 | 0.533 | –1.09 | –0.75 | 0.452 | 0.79 | 0.84 | 0.399 | 0.622 | – | 73.33% | 73.33% |
| BDNF Met + (n = 25; 16 NT, 9 ASD) | ||||||||||||
| T15 ΔMEP | 5.20 | 0.023 | –2.12 | –1.98 | 0.048 | –0.50 | –1.04 | 0.296 | 0.689 | 100.00% | 78.95% | 83.33% |
| T15 ΔMEP plus Education† | 5.25 | 0.073 | –2.09 | –1.92 | 0.055 | –.05 | –.21 | 0.833 | 0.711 | 100.00% | 83.33% | 87.50% |
| T15 ΔMEP plus Race | 5.90 | 0.052 | –1.84 | –1.68 | 0.093 | 0.86 | 0.83 | 0.408 | 0.682 | 85.71% | 82.35% | 83.33% |
| APOE ε– (n = 36; 26 NT, 10 ASD) | ||||||||||||
| T15 ΔMEP | 5.46 | 0.019 | –2.11 | –2.09 | 0.037 | – | – | – | 0.688 | 100.00% | 77.42% | 79.41% |
| T15 ΔMEP plus Education† | 9.48 | 0.009 | –2.03 | –1.85 | 0.064 | –0.63 | –2.04 | 0.041 | 0.828 | 83.33% | 84.00% | 83.87% |
| T15 ΔMEP plus Race | 5.48 | 0.065 | –2.15 | –2.06 | 0.040 | –0.12 | –0.14 | 0.892 | 0.671 | 100.00% | 77.42% | 79.41% |
| APOE ε+ (n = 19; 13 NT, 6 ASD) | ||||||||||||
| T15 ΔMEP | 1.67 | 0.197 | –2.18 | –1.21 | 0.228 | – | – | – | 0.705 | 100.00% | 72.22% | 73.68% |
| T15 ΔMEP plus Education† | 4.42 | 0.110 | –1.68 | –0.86 | 0.388 | 0.63 | 1.51 | 0.131 | 0.789 | – | 73.33% | 64.71% |
| T15 ΔMEP plus Race | 4.81 | 0.091 | –1.85 | –1.06 | 0.288 | 2.02 | 1.61 | 0.108 | 0.808 | 66.67% | 84.62% | 78.95% |
| APOE ε+ (n = 19; 13 NT, 6 ASD) | ||||||||||||
| T30 ΔMEP | 3.69 | 0.055 | –2.63 | –1.62 | 0.106 | – | – | – | 0.795 | 100.00% | 76.47% | 78.95% |
| T30 ΔMEP plus Education† | 5.63 | 0.060 | –1.92 | –1.30 | 0.193 | 0.63 | 1.40 | 0.163 | 0.827 | 50.00% | 84.62% | 76.47% |
| T30 ΔMEP plus Race | 8.19 | 0.017 | –2.93 | –1.73 | 0.083 | 2.60 | 1.87 | 0.062 | 0.859 | 80.00% | 1.20% | 84.21% |
Models in each genetic subgroup are ranked based on their % Dx. Diagnosis was 0 for NT and 1 for ASD. IV refers to ΔMEP at T15 or T30, as specificed. Race was 0 for White and 1 for non-White. Racial categories were defined according to the National Institutes of Health guidelines (NIH Office of Extramural Research, 2001). Significant p-values are in bold font. In each subgroup, the highest % Dx value of a significant model is in bold font. % Dx, percentage correctly classified; APOE, apolipoprotein E; ASD, autism spectrum disorder; AUROC, area under the receiver operating characteristic curve; BDNF, brain-derived neurotrophic factor; IV, independent variable; LR, likelihood ratio; ΔMEP, baseline-corrected, natural log-transformed amplitude of the motor evoked potential; Met, metionine; NPV, negative predictive value; NT, neurotypical; PPV, positivie predictive value; Tn, n minutes post-cTBS.
APOE data were available for 16 and 39 participants in the ASD and NT groups, respectively.
Education data were available for 16 and 42 participants in the ASD and NT groups, respectively.
BDNF data were available for 17 and 39 participants in the ASD and NT groups, respectively.