Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Neurobiol Dis. 2021 May 1;155:105384. doi: 10.1016/j.nbd.2021.105384

Figure 2.

Figure 2.

(A) Representative images of T2*-weighted MRI scans from 4, 24 and 72 hours after intraventricular injection of 200 μl autologous blood with IgG (IVH+IgG) or CD47 blocking antibody (IVH+anti-CD47) in F344 rats. Intraventricular lesion and intra-hematoma non-hypointense lesions can be noted. (B) Intraventricular lesion volumes were quantified using T2*-weighted images at 4, 24- and 72-hours post-surgery. Note the significant reduction at 24 and 72 hours in the anti-CD47 group. (C) Intraventricular non-hypointense lesion volumes were quantified using T2*-weighted images at 24- and 72-hours post-surgery. Note again the significant reduction at 24 and 72 hours in the anti-CD47 group. (D) The ratios of intraventricular non-hypointense lesion volume to T2* lesion volume were calculated at 24- and 72-hours post-surgery and showed the relative reduction in non-hypointense lesion volume in the anti-CD47 group. Values are shown as mean ± SD; n = 5–6 per group in 4h, n = 9 per group in 24h and 72h, * p < 0.05 IVH+anti-CD47 vs. IVH+IgG group; ** p < 0.01 IVH+anti-CD47 vs. IVH+IgG group.