Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 12;12(6):609. doi: 10.1038/s41419-021-03895-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Heat maps of histones and variants in 23 HCC and paired paracancer tissues analyzed using RNA-seq(Software: R pheatmap, Algorithm: ward2). b H2A.Z transcript between HCC tissues and normal liver tissues was analyzed in the publicly accessible samples(TCGA http://gepia.cancer-pku.cn/; T = 375, N = 50)(Software: beeswarm, R package). c Scatter plots comparing H2A.Z expression in HCC samples and normal liver tissue samples detected by qPCR(Student’s t-test used in Fig c, n = 30 in each group). d The expression levels of H2A.Z in human HCC cells were detected by qRT-PCR. e Expression levels of H2A.Z protein were detected in 8 matched HCC samples by western blot (N, normal tumor-adjacent tissue; T, tumor tissue). f Expression levels of H2A.Z protein were detected in HCC cell lines by western blot. g Kaplan-Meier survival curves illustrating the overall survival and disease-free survival of patients with HCC associated with H2A.Z expression in 96 cases. h The negative correlation between H2A.Z expression and overall survival was analyzed on the basis of TCGA data in patients with HCC(Software: survival, R package). The data are expressed in terms of mean ± SD(Student’s t-test used in Fig d and Kaplan-Meier test used in Fig g; **P < 0.01; ***P < 0.001; ****P < 0.0001; n = 3 in each group).