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. 2021 Jun 12;12(6):609. doi: 10.1038/s41419-021-03895-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Identification of the H2A.Z transfection effect detected by western blot. b The proliferation capability of cells was detected by MTT assays. c, d Transwell assay was adopted to test cell migration and invasion under different contexts(Scale bars: 50 μm). e Flow cytometry was utilized to test the apoptotic cells. f A subcutaneous tumor model in nude mice was used to test the tumor-forming ability of cell lines with different treatments. g A mouse lung metastasis model was used to detect cell metastasis under different contexts (The black arrow marks the metastases) (Scale bars: 100 μm). The data are expressed in terms of mean ± SD (Student’s t-test used in Fig b–g; *P < 0.05; **P < 0.01; ***P < 0.001. ****P < 0.0001; n = 3 in each group).