Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 12;12(6):609. doi: 10.1038/s41419-021-03895-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a H2A.Z mainly promoted the transcription of downstream genes(Software: BETA, algorithm: basic-k BSF-df 0.05). b The acetylation level of H2A.Z was detected by Co-IP in HCC cell lines. c The acetylation level of H2A.Z was detected by Co-IP in HCC tissues. d RIP with H2A.Zac antibody in HepG2 cells and sequencing. e Volcanograms of lincRNA identified by RIP-seq(Software: ggplot2, R package). f Heat maps and volcanograms of the seven pairs of HCC and paired paracancer tissues analyzed by RNA-seq(Software: R pheatmap, R package). g Venn diagram of RIP-seq and lincRNA highly expressed in tumors in RNA-seq. h IGV diagram of lincZNF337-AS1. i–j Identification of lincZNF337-AS1 binding to H2A.Z and H2A.Zac by RIP-qPCR. k–l LincZNF337-AS1 regulates the acetylation of HCC, the level of acetylation was measured by Co-IP. m, n QRT-PCR, and western blot verified the changes of downstream target genes after lincZNF337-AS1 knockdown in H2A.Z overexpressed HCC cell lines. The data are expressed in terms of mean ± SD (Student’s t-test used in Fig i, j, and n; **P < 0.01; ***P < 0.001; ****P < 0.0001; n = 3 in each group).