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. 2021 Jun 12;12(6):609. doi: 10.1038/s41419-021-03895-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic diagram of lincZNF337-AS1 full-length and truncated fragments. b The interaction of lincZNF337-AS1 truncated fragments with H2A.Z in HEK293T cells was verified by a RIP-qPCR assay. c, d RNA-pulldown assay verifies the binding site of lincZNF337-AS1 to H2A.Z in HCC cells. e Scatter plots comparing lincZNF337-AS1 expression in HCC samples and normal liver tissue samples detected by qPCR (Student’s t-test used in Fig e, n = 30 in each group). f The positive correlation between lincZNF337-AS1 and H2A.Z expression was analyzed on the basis of data of 30 HCC samples. g LincZNF337-AS1 transcript between HCC tissues and normal paracancer tissues was analyzed in the publicly accessible samples(TCGA http://gepia.cancer-pku.cn/, T = 375; N = 50, Software: beeswarm, R package). h Kaplan–Meier survival curves illustrating the overall survival and disease-free survival of patients with HCC associated with lincZNF337-AS1 expression in 96 cases. i The negative correlation between lincZNF337-AS1 expression and overall survival was analyzed on the basis of TCGA data in patients with HCC(Software: survival, R package). j The positive correlation between lincZNF337-AS1 and H2A.Z expression was analyzed on the basis of TCGA data in patients with HCC(Software: ggplot2, R package). k, l The proliferation capability of cells was detected by colony formation assay and EdU assay (scale bar = 50 μm). The data are expressed in terms of mean ± SD (Student’s t-test used in b, k, and l; Kaplan-Meier test used in g; Linear regression test used in j; ****P < 0.0001; n = 3 in each group).