We analyzed the positivity rates for norovirus and other enteric pathogens from 2016 to 2020.

We observed that norovirus rates were dramatically reduced and sustained in 2020 coinciding with the onset of the COVID-19 pandemic and mitigation factors to prevent COVID-19.

Initial reductions in positive rates for other enteric pathogens were observed for several months at the beginning of the COVID-19 pandemic, but returned to historical rates.

The study provides some insight into the mechanisms for norovirus infection reduction associated with interventions to prevent COVID-19 infections during the past year.