Table 2.

Tabular overview of the most important information on the role of Snail-1 in cancerogenesis in thyroid glands.

	References
The EMT process in the context of thyroid cancer and Snail-1
Expression of Snail-1, TGF-β1 and MMP-9 is significantly correlated with lymph node metastases in PTC	Wang et al., 2014 [38].
Snail-1 expression is proportional to the advanced stages of PTC	Mato et al., 2014 [41]
The interplay of BRAFV600E and Snail-1 in thyroid cancer
Overexpression of BRAFV600E enhances the upregulation of the Snail-1 protein and induces cell migration and invasion	Baquero et al., 2013 [48]
BRAFV600E induces TGF-β secretion in thyroid cancer cells; BRAFV600E, TGF-β and the Src/FAK complex cooperate in the regulation of EMT induction and cell motility	Baquero et al., 2016 [51]
SNAI1’s increased expression directly correlates with a BRAFV600E-positive status, especially in metastatic PTC tissue	Wieczorek-Szukala et al., 2020 [42]
The expression of Snail-1 in thyroid tissue
Snail-1 is overexpressed in cell lines derived from thyroid carcinomas, in human thyroid carcinoma samples and metastases; Snail-1 is involved in tumour formation and dissemination during the metastasising process	Hardy et al., 2007 [62]
Snail-1 expression is higher in WI-FTC, PDTC and ATC, but decreased in follicular adenomas and MI-FTC tissues	Wu et al., 2019 [63]
Snail-1 overexpression occurs in the invasive fronts rather than tumour center areas of high-grade follicular cancer	Wu et al., 2019 [63], Heiden et al., 2014 [68]
Snail-1 is implicated in the formation of thyroid cancer stem cells
Snail-1 overexpression induces sphere formation in ALDH—cells	Yasui et al., 2013 [71].
Shh pathway plays a key role in maintaining the CSC self-renewal in ATC cells	Heiden et al., 2014 [68]
Murine BRAFV600E-positive PTC cells with Snail-1 overexpression gain a CSC-like phenotype and migratory potential	Ma et al., 2014 [70]
IL-6 stimulates Snail-1 expression in thyroid CSC derived from ATC cell lines [74]	Zheng et al., 2019 [74]
Snail-1 induces chemoresistance in thyroid cancer
High expression of ABCG2 correlates with the overexpression of Snail-1, Twist1 and ZEB1 genes in PDTC, ATC and PTC tissues	Mato et al., 2014 [41]
miRNA and Snail-1 in thyroid cancer
miR-199a-5p inhibits PTC progression by targeting SNAI1; its overexpression reduces cell migration, invasion, the EMT process and PTC tumour growth in xenografts	Ma et al., 2018 [89]
miR-215 inhibits EMT via the ARFGEF1-activated AKT/GSK-3β/Snail signaling in PTC cells and tissue	Han et al., 2019 [92]
The overexpression of miR-150-5p induces the expression of mesenchymal markers, including Snail-1, in PTC cell lines with BRAFV600E	Yan et al., 2018 [95]