Table 4.
Clinical studies with milk-or colostrum-based products.
| Product Used | Type of Disease or Healthy Skin (Number of Patients) | Result of the Study | [Ref.] |
|---|---|---|---|
| Topically applied milk-based products | |||
| bovine colostrum preparation (supported antibiotic therapy) | difficult-to-heal wounds caused by buttock erythematosus and by erosion erythema | significant improvement in wound healing | [174] |
| ointments containing 10% and 20% lactoferrin | moderate psoriatic plaque (n = 22) | improvement in elevation, redness, and scaling of psoriatic lesions | [114] |
| soap containing 5% Podolian cow milk | healthy skin | good cleansing and antibacterial properties | [175] |
| creams with skimmed donkey milk encapsulated in nanoliposomes | healthy skin (n = 15) | satisfactory moisturizing properties; antiaging effects | [176] |
| cream containing 30% horse colostrum | seborroic acne (n = 12) | complete skin regeneration | [177] |
| cream containing 20% horse colostrum and 10% horse milk (plus mint and benzocaine) | contact skin lesions (n = 5) | resolution of contact skin lesions and pain immediately after application | [177] |
| cream containing 20% horse colostrum and 10% horse milk (plus mint and benzocaine) | hyperthermia sunburn skin (n = 30) | immediate relief of pain and skin tension (within 24 h); the appearance of a normal tan, without any scale-off skin effect | [177] |
| cream containing 20% horse colostrum and 10% horse milk (plus mint and benzocaine) | 2° degree and 3° fire burns (n = 8) | rapid pain relief; rebuilding the epithelium in a week | [177] |
| emulsion with 20% horse colostrum | moderate atopic dermatitis (n = 7) | reduction in erythema and pruritus; softening, moisturizing, soothing, and anti-inflammatory effects | [177] |
| liposomal gel containing 20% horse colostrum | ulcerative skin lesions (n = 10) | improvement of skin healing and repair | [177] |
| cosmetic formulations based on a combination of horse colostrum and horse milk | healthy skin | antiaging, moisturizing, protective, tensio-distensive, tonic, smoothing, anti-irritant, emollient, bleaching, decongestant, and sebostatic effects | [177] |
| fermented (by lactic acid bacteria) horse colostrum | atopic dermatitis (atopy and psoriasis) | alleviating symptoms; moisturizing and anti-inflammatory effects |
[178] |
| fermented colostrum | acne | improvement related to the antibacterial effect | [179] |
| formulations containing bovine or equine colostrum (plus hyaluronic acid or its salt and olive oil or vitamin E) | healthy skin of elderly volunteers | improvement elasticity and tension; moisturizing and antioxidant effects; reduction in skin sagging and liver spots | [180] |
| cosmetic formulation based on colostrum albumin (plus arbutin) | healthy skin with discoloration | whitening properties | [181] |
| Milk-based products used as supplements | |||
| fermented milk enriched with lactoferrin | acne vulgaris (n = 18) | reduction in inflammation, sebum content, and the severity of acne lesions | [90] |
| lactoferrin | mild to moderate common acne | overall improvement in acne lesions | [170] |
| capsules containing lactoferrin (plus vitamin E and zinc) | acne | reduction in the number of acne lesions, blackheads, and inflammatory changes; regulation of sebum secretion | [173] |