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Schematic representation of different stages in the spectrum of cellular senescence and EMT. Circumventing senescence, precipitated by stress (e.g., therapy or nutrients starvation), accompanied by the acquisition of stem cell properties gives rise to highly proliferative, tumorigenic cells, unable to proceed either to fully senescent (mitotically incompetent) or fully mesenchymal state (xE and E-epithelial; E/M-hybrid epithelial/mesenchymal; M and xM-mesenchymal).
