Figure 1.

Reparameterization of the Kharche et al. model of the murine SAM. (A) Experimental (top panels) and simulated (bottom panels) voltage-dependence of peak I_CaL [24], peak I_to [25], and I_f availability [26]. (B) Parameter scaling factors yielded by the global optimization process aimed at minimizing the differences between average measured and simulated AP characteristics (shown in the schematic in the inset). Definition of both model parameters and AP characteristics is reported in Appendix A. (C) Time course of membrane voltage in a representative experimental trace and in simulations performed with the original Kharche et al. model (orange) and our optimized dataset-specific reparameterization (blue). (D) Comparison between experimentally measured AP characteristics [23] and the outputs predicted with original and optimized models.