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. 2021 May 26;22(11):5645. doi: 10.3390/ijms22115645

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Properties of the newly developed dataset-specific model of the murine SAM. (A) Time course of AP, Ca²⁺ and Na⁺ concentrations, and main ion currents in the optimized model. (B) Simulated and experimentally observed effects on FR induced by complete block of I_Na1.1 and I_Na1.5 [28,29], I_to and I_sus [29], I_CaT [30], I_CaL [31], NCX [32], and NKA [33]. “Stop” indicates interruption of spontaneous firing activity.