Table 2.

Evaluated variables in included studies. * timing of evaluation: 30 min WIT, 15 min R. AI, apoptosis index; BAX, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2 protein; C3, caspase-3; C9, caspase-9; CAT, catalase; CK, creatine kinase; CI, cardiac injury; dP/dt_max, maximal pressure rise; dP/dt_min, minimal pressure rise; EF, ejection fraction; FR, flow rate; GPx, glutathione peroxidase; GR, glutathione reductase; GSH, glutathione; HR, heart rate; LDH, lactate dehydrogenase; LVDP, left ventricular develop pressure; LVEDP, left ventricular end-diastolic pressure; MDA, malondialdehyde; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; RPP, rate pressure product; SOD, superoxide dismutase; STAT3, signal transducer and activator of transcription 3.

ID	Author	Infarct Size	CI Markers	Apoptosis Markers	Oxidative Stress Markers	Cardiac Function	Timing of Evaluation
1	Kannan et al. [23]	Yes	CK, LDH		GSH, SOD, CAT, GPx, GR	LVDP, HR, RPP	90 min (30 min WIT, 60 min R)
2	Sun et al. [21]	No	CK, cTnI	C3, BAX, AI	GSH, SOD, CAT, MDA	LVDP, dP/dtmax, EF, arrhythmia	270 min (240 min CIT, 30 min R)
3	Ravindran et al. [24]	Yes	CK, LDH		SOD, CAT, GPx, GR, PGC-1α	LVDP, HR	90 min (30 min WIT, 60 min R)
4	Ansari et al. [25]	Yes	CK, LDH	C3		LVDP, LVEDP, RPP	105 min (30 min WIT, 75 min R)
5	Ravindran et al. [26]	Yes	CK, LDH		GSH, SOD, CAT, GR, GPx, MDA	LVDP, LVEDP, dP/dtmax, RPP	90 min (30 min WIT, 60 min R)
6	Ansari et al. [27]	Yes	CK, LDH	C3	GSH, CAT, GR, GPx, MDA	LVDP, LVEDP, RPP	90 min (30 min WIT, 60 min R)
7	Hu et al. [16]	Yes	CK, LDH		SOD, MDA, PGC-1α	LVDP, LVEDP, LVDP, LVEDP, dP/dtmax, RPP	90 min (30 min WIT, 60 min R)
8	Chen et al. [17]	Yes	CK, LDH	Bcl-2, AI	SOD, MDA	LVDP, LVEDP, LVDP, LVEDP, dP/dtmax	100 min (40 min WIT, 60 min R)
9	Zhang et al. [28]	No				LVDP, dP/dtmax, arrhythmia	60 min (30 min WIT, 30 min R)
10	Sun et al. [29]	Yes				LVDP, LVEDP, dP/dtmax and dP/dtmin,HR, RPP, FR	110 min (20 min WIT, 90 min R)
11	Ji et al. [22]	Yes	CK *			LVDP, HR	120 min (30 min WIT, 90 min R)
12	Luan et al. [19]	Yes		Bcl-2, BAX, STAT3, AI		LVDP, LVEDP, dP/dtmax, HR	120 min (30 min WIT, 90 min R)
13	Hu et al. [30]	No		AI		LVDP, dP/dtmax, dP/dtmin	390 min (360 min CIT, 30 min R)
14	Alves et al. [31]	No		Bcl-2		LVDP, LVEDP, HR	270 min (240 min CIT, 30 min R)
15	Li et al. [18]	Yes	CK, LDH	C3, C9, Bcl-2, AI	SOD, MDA	LVDP, LVEDP, dP/dtmax. dP/dtmin	100 min (40 min WIT, 60 min R)
16	Minamishima et al. [32]	No				LVDP, dP/dtmax, dP/dtmin, RPP, FR	80 min (20 min, WIT 60 min R)