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. 2021 Jun 1;13(11):2740. doi: 10.3390/cancers13112740

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Exercise promotes migration of bone marrow (stem) cells into the heart after Dox treatment. (A) Representative immunofluorescence images of heart sections stained for DAPI (blue) and GFP (green) from Ctr, Ex, Dox, and Dox+Ex group mice. Magnification, 40×; Scale bar, 50 µm. (B) Quantification of GFP-positive cells in heart tissues per 10× field from Ctr, Ex, Dox, and Dox+Ex group mice. N = 5 mice/group, 3 slides/mouse. Values represent mean ± SEM. P values are indicated by the Student’s t test. (C) Representative immunofluorescence images of heart sections stained for DAPI (blue), GFP (green), and c-Kit (red) from Ctr, Ex, Dox, and Dox+Ex group mice. Magnification, 400×; Scale bar, 5 µm. (D,E) Quantification of the number and percentage of c-Kit and GFP double-positive cells in heart tissues per 10× field and per total c-Kit-positive cells from Ctr, Ex, Dox, and Dox+Ex group mice. N = 5 mice/group, 3 slides/mouse. Values represent mean ± SEM. p values are indicated by the Student’s t test.

Exercise promotes migration of bone marrow (stem) cells into the heart after Dox treatment. (A) Representative immunofluorescence images of heart sections stained for DAPI (blue) and GFP (green) from Ctr, Ex, Dox, and Dox+Ex group mice. Magnification, 40×; Scale bar, 50 µm. (B) Quantification of GFP-positive cells in heart tissues per 10× field from Ctr, Ex, Dox, and Dox+Ex group mice. N = 5 mice/group, 3 slides/mouse. Values represent mean ± SEM. P values are indicated by the Student’s t test. (C) Representative immunofluorescence images of heart sections stained for DAPI (blue), GFP (green), and c-Kit (red) from Ctr, Ex, Dox, and Dox+Ex group mice. Magnification, 400×; Scale bar, 5 µm. (D,E) Quantification of the number and percentage of c-Kit and GFP double-positive cells in heart tissues per 10× field and per total c-Kit-positive cells from Ctr, Ex, Dox, and Dox+Ex group mice. N = 5 mice/group, 3 slides/mouse. Values represent mean ± SEM. p values are indicated by the Student’s t test.