Table 1.

Gene Expression Studies that Defined HPV(+) HNSCC Subtypes.

Citation	HPV(+) Subtype Names	Figure Abbr	Data Used to Define Subtypes	Sample Size	Sites
Pyeon et al., 2007	α (B cell strong), β (highly keratinized)	-	Expression microarrays	16 HPV(+); 26 HPV(−)	Oropharynx; oral cavity
Keck et al., 2015	IMS (immune strong), BA (basal-like), CL (classical)	KECK	Expression microarrays	371 total; 55 HPV(+); 75 HPV(−) *	Oropharynx; oral cavity; larynx
TCGA 2015	Atypical, Basal, Classical, Mesenchymal	NAT	RNAseq	36 HPV(+); 243 HPV(−)	All HNSCC
Zhang et al., 2016	IMU (immune strong); KRT (highly keratinized)	CCR	RNAseq	84 HPV(+); 18 HPV(−)	Oropharynx; oral cavity
Lee et al., 2018	1 (cervical-like); 2 (HNSCC classical); 3 (lung-like)	ORA	RNAseq	1346 total; 514 HNSCC; 65 HPV(+)	HNSCC, esophageal, lung, cervical
Locati et al., 2019	Cl1 (immune strong, high stromal); Cl2 (highly keratinized; high stromal); Cl3 (highly keratinized; low stromal)	CAN	RNAseq and microarrays meta-analysis	346 HPV(+)	Oropharynx, oral cavity, larynx, hypopharynx

* For Keck et al., only 130 have known HPV status.