Table 4.
Odds ratios and relative risk of prostate cancer in men aged 50–75 years at varying event frequencies in the intervention group with no change in the sample size.
| Prostate Cancer | No Prostate Cancer | Row Total | Odds of Cancer | Odds Ratio | Risk of Cancer | Relative Risk | |
|---|---|---|---|---|---|---|---|
| Hypothetical study population with increased disease frequency (n = 6729) | |||||||
| Intervention | (↑↑↑) 2000 | (↓↓↓) 1305 | (--) 3305 | 2000/1305 = 1.53 | 1.53/0.33 = 4.64 | 2000/3305 = 0.61 | 0.61/0.25 = 2.44 |
| Control | (--) 858 | (--) 2566 | (--) 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
| Intervention | (↑↑) 1000 | (↓↓) 2305 | (--) 3305 | 1000/2305 = 0.43 | 0.43/0.33 = 1.30 | 1000/3305 = 0.30 | 0.30/0.25 = 1.20 |
| Control | (--) 858 | (--) 2566 | (--) 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
| Intervention | (↑) 828 | (↓) 2477 | (--) 3305 | 828/2477 = 0.33 | 0.33/0.33 = 1.0 | 828/3305 = 0.25 | 0.25/0.25 = 1.0 |
| Control | (--) 858 | (--) 2566 | (--) 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
| Actual study population (n = 6729) | |||||||
| Dutasteride | 659 | 2646 | 3305 | 659/2646 = 0.25 | 0.25/0.33 = 0.76 | 659/3305 = 0.20 | 0.20/0.25 = 0.8 |
| Control | 858 | 2566 | 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
| Hypothetical study population with decreased disease frequency (n = 6729) | |||||||
| Intervention | (↓) 100 | (↑) 3205 | (--) 3305 | 100/3205 = 0.03 | 0.03/0.33 = 0.09 | 100/3305 = 0.03 | 0.03/0.25 = 0.12 |
| Control | (--) 858 | (--) 2566 | (--) 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
| Intervention | (↓↓) 10 | (↑↑) 3295 | (--) 3305 | 10/3295 = 0.003 | 0.003/0.33 = 0.009 | 10/3305 = 0.003 | 0.003/0.25 = 0.012 |
| Control | (--) 858 | (--) 2566 | (--) 3424 | 858/2566 = 0.33 | 858/3424 = 0.25 | ||
Note: ↑/↓/-- denote an increase/decrease/no change in prostate cancer disease frequency in the hypothetical study populations relative to the actual study population, respectively.