Figure 3.

Prognostic impact of different WBC-MRD cut-off values. (A) Using MaxStat analysis, optimal cut-off values of 0.03% and 0.1% were identified (X-axis denotes % WBC-MRD). In contrast to PM-MRD, the cut-off points are not that clear, especially for a cut-off value of 0.1%. (B) Using the cut-off of 0.03%, two patient groups showed an EFS of 40.0% for WBC-MRD^positive patients and an EFS of 55.9% for WBC-MRD^negative patients. (C) For the 0.1% cut-off values, these groups showed an EFS of 37.5% for MRD^positive patients and an EFS of 53.8% for MRD^negative patients. (D) When both were combined, three patient groups with different EFS were shown: 55.9%, 43.9%, and 37.5%.