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. 2021 May 31;13(11):2725. doi: 10.3390/cancers13112725

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Course of disease, treatment, and morpho-molecular workup of patient 3. (A) Timeline. (B) Histology of the primary tumor; PET MIP display and fused PET/CT image at primary diagnosis. (C) Histology of the lymph node metastasis; PET MIP display and fused PET/CT image at progression after 34 cycles of pembrolizumab. (D) Histology of the colon metastasis; PET MIP display and fused PET/CT image at progression under nivolumab/relatlimab. (E) PET MIP display and fused PET/CT image at CR. (F) Histology of the adrenal gland metastasis; PET MIP display and fused PET/CT image at progression without therapy. Scale bar: 40 µm. wt: wild type, LN: lymph node, CR: complete remission.