Table 2.

Comparison of tumor histology.

	Size	Morphology	Nuclei	Other Features	Main Molecular Alteration
Patient 1
Primary diagnosis	medium/large	pleomorphic, atypical	variable size, prominent nucleoli, eccentric nuclei	eosinophilic cytoplasm, abundant mitoses	KRAS p.G12R
Extensive resection	medium/large	pleomorphic, atypical	convoluted nuclei, variable size, prominent nucleoli, eccentric nuclei	eosinophilic cytoplasm, abundant mitoses	KIT p.D816H
Liver biopsy				few vital cells, myxoid stromal changes	WT
Soft tissue metastasis	medium/large	pleomorphic, atypical	chromatin clearing of the nuclei	eosinophilic cytoplasm, abundant mitoses	NRAS p.Q61R
Patient 2
Primary diagnosis	medium/large	monomorphic, atypical	variously distinct nucleoli	eosinophilic cytoplasm	KRAS p.G12A/amplification
Local recurrence 1	spindle cells: medium/large; epithelioid cells: small	biphasic appearance (spindle cell shaped, monomorphic epithelioid)			NRAS p.Q61K
Local recurrence 2	small/ medium	monomorphic, atypical			NRAS p.Q61K
Patient 3
Primary diagnosis	medium/large	atypical, epithelioid	prominent nucleoli	eosinophilic cytoplasm, abundant mitoses	WT
LN level II	medium/large	atypical, epithelioid	prominent nucleoli	eosinophilic cytoplasm, abundant mitoses	WT
Hemi- colectomy	medium/large	atypical, epithelioid	prominent nucleoli	eosinophilic cytoplasm, abundant mitoses	PIK3CA p.C420R
Adrenal gland metastasis	small/ medium	atypical, epithelioid	lacking prominent nucleoli	eosinophilic cytoplasm, abundant mitoses	NRAS p.Q61K

LN = lymph node, WT = wild type, major differences are printed in bold.