APP/PS1 mice |
APP/PS1 mice overexpress human APP with Swedish mutation (K670N and M671L) and presenilin 1, bearing an L166P mutation in neurons driven by thymocyte differentiation antigen 1 (Thy-1) promoter [343]. |
APP/PS2 mice |
APP/PS2 mice overexpress human APP with the Swedish mutation and presenilin 2, bearing an N141I mutation driven by the Thy-1 promoter and prion protein (Prnp) promoter, respectively [344,345]. |
APPswe mice |
APPswe mice overexpress human APP with the Swedish mutation driven by the Prnp promoter [346]. |
APP23 mice |
APP23 mice overexpress human APP with the Swedish mutation in neurons driven by the Thy-1 promoter [347]. |
hAPPJ20 mice |
hAPPJ20 mice overexpress human APP with the Swedish mutation and Indiana mutation (V717F) in neurons driven by platelet-derived growth factor (PDGF)-β promoter [348]. |
MLC/mIGF-1 |
MLC/mIGF-1 mice express rat mIGF-1, an isoform of IGF-1, cDNA driven by skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus [349]. |
N171-82Q mice |
N171-82Q mice express an N-terminally truncated huntingtin cDNA that contains 82 glutamines and encompasses the first 171 amino acids of huntingtin (N171-82Q) driven by the Prnp promoter [350]. |
PS19 mice |
PS19 mice overexpress human tau with a mutation (P301S) driven by the Prnp promoter [351] |
R1Mab1 |
R1Mab1 is an IgG humanized monoclonal antibody with agonistic activity on the fibroblast growth factor receptor 1 (FGFR1) [213]. |
SOD-G93A mice |
SOD-G93A mice overexpress human SOD1 with a mutation (G93A) and develop adult-onset motor neuron loss [352]. |
Tau P301L mice |
Tau P301L mice overexpress human tau with a mutation (P301L) in neurons driven by the Thy-1 promoter [353]. |