Table 2.
Publications identified by the PubMed search on quality of life in patients with GvHD with specific results on severe cGvHD.
| First Author, Year, Country | Study Design | Form of GvHD | Patient Population | Main Outcomes | Main Results on Severe GvHD |
|---|---|---|---|---|---|
| Pidala, 2011, USA [44] | Cross-sectional | cGvHD | 298 study participants; 30.9% had severe cGvHD | Association of patient-reported QoL and the severity of cGvHD | Severe cGvHD was associated with worse patient-reported QoL compared to milder forms of cGvHD. |
| Baird, 2013, USA [10] | Cross-sectional | cGvHD | 189 study participants; 66% had severe cGvHD | Assessment of the validity of the NIH criteria as determinants in severely affected patients | Participants with more severe cGvHD showed worse outcomes in nearly all QoL measures compared to milder forms of cGvHD. |
| Kurosawa, 2017, Japan [45] | Cross-sectional | cGvHD | 1140 study participants; 9% of patients had severe cGvHD | Association of patient-reported QoL and the severity of cGvHD | Severe cGvHD was associated with worse patient-reported QoL compared to milder forms of cGvHD. |
| Mo, 2013, China [46] | Cross-sectional | cGvHD | 264 study participants; 19.3% had severe cGvHD | Association of patient-reported QoL and the severity of cGvHD | Severe cGvHD was associated with worse patient-reported QoL compared to milder forms of cGvHD. |
| Pidala, 2011, USA [47] | Prospective cohort | cGvHD | 336 study participants; 27% had severe cGvHD at the beginning of the study | Association of changes in cGvHD severity (measured by NIH criteria by the clinician as well as patient-reported) | Changes in NIH-assessed cGvHD severity did not have an impact on changes in QoL, but changes in patient-reported cGvHD severity were associated with changes in QoL measures. |
| Agh, 2019, Hungary [38] | Systematic review | cGvHD | n.a. | Systematic overview of HRQoL and functional capacity of patients with cGvHD | Four of five included studies that assessed the impact of cGvHD severity on HRQoL found significantly worse HRQoL in patients with more severe cGvHD. |
cGvHD: chronic graft-versus-host disease; HRQoL: health-related quality of live; n.a.: not applicable; NIH: National Institutes of Health; QoL: quality of life.